Rövid leírás:

Organic chemistry is the science of carbon-containing compounds. There are four major types of reactive intermediates in organic chemistry: carbocations, carboanions, radicals and carbenes. Therefore, carbocation chemistry is not only fundamental to the advancement of organic chemistry, it also has found widespread applications in organic synthe

Hosszú leírás:

Carbocation chemistry is not only fundamental to the advancement of organic chemistry, it also has found widespread applications in organic synthesis. It is not an exaggeration to say that carbocation chemistry is part of the foundation of organic chemistry. Carbocation Chemistry: Applications in Organic Synthesis provides a panoramic view of carbocation chemistry with an emphasis on synthetic applications.

This book is an invaluable tool for organic, medicinal and analytical chemists, including those working in biochemistry as well as the petroleum, plastics and pharmaceutical industries. It is also suitable for upper level undergraduates and graduates in organic chemistry, biochemistry and medicinal chemistry.

Tartalomjegyzék:

Chapter 1. Introduction

1. Nomenclature, Structure, and Stability



2. Generation of Carbocations



3. The Non-Classical Ion Controversy



4. Electrophilic Addition to Alkenes



5. Electrophilic Aromatic Substitution



6. Elimination reactions



7. Rearrangement Reactions of Carbocations



8. References

Chapter 2. Nucleophilic Aliphatic Substitution ? S_N1

1. Introduction



2. -Activated Alcohols?Br?nsted Acids



3. -Activated Alcohols?Lewis Acids



4. Alkylation of Aldehydes and Ketones



5. Glycosylation



6. Friedel?Crafts Alkylation and Acylation



7. Electrophilic Fluorination Using Fluoronium Ion



8. Miscellaneous S_N1-related Reactions



9. References

Chapter 3. Nucleophilic Aliphatic Substitution ? S_N2

1. Construction of Quaternary Stereogenic Centers



2. Sulfur Chemistry



3. Organometallic Chemistry



4. Macrocyclization



5. Glycosylation



6. Nucleoside Analogues



7. N-Alkylation



8. Cyclotetraphosphazenes



9. Conformationally Locked Tetrahydropyran Ring



10. The Ionic Liquid Effect



11. Silver Chemistry



12. References

Chapter 4. Electrophilic Addition to Alkenes

1. Introduction



2. Cyclopropanation



3. Hydroboration/Oxidation



4. The Pauson?Khand Reaction



5. Prins Reaction



6. Schmidt Reaction



7. Halogenation



8. Oxymercuration/Reduction



9. Epoxidation



10. Gold-Catalyzed Alkyne Hydration



11. Conclusion



12. References

Chapter 5. Electrophilic Aromatic Substitution

1. Introduction



2. Nitration



3. Halogenation



4. Friedel?Crafts Alkylation



5. Friede
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