Vanishing Bone
Conquering a Stealth Disease Caused by Total Hip Replacements
- Publisher's listprice GBP 23.99
-
10 831 Ft (10 315 Ft + 5% VAT)
The price is estimated because at the time of ordering we do not know what conversion rates will apply to HUF / product currency when the book arrives. In case HUF is weaker, the price increases slightly, in case HUF is stronger, the price goes lower slightly.
- Discount 20% (cc. 2 166 Ft off)
- Discounted price 8 665 Ft (8 252 Ft + 5% VAT)
- Discount is valid until: 30 June 2026
Subcribe now and take benefit of a favourable price.
Subscribe
10 831 Ft
Availability
Estimated delivery time: In stock at the publisher, but not at Prospero's office. Delivery time approx. 3-5 weeks.
Not in stock at Prospero.
Why don't you give exact delivery time?
Delivery time is estimated on our previous experiences. We give estimations only, because we order from outside Hungary, and the delivery time mainly depends on how quickly the publisher supplies the book. Faster or slower deliveries both happen, but we do our best to supply as quickly as possible.
Product details:
- Publisher OUP USA
- Date of Publication 1 February 2018
- ISBN 9780190687762
- Binding Hardback
- No. of pages248 pages
- Size 211x147x27 mm
- Weight 476 g
- Language English 0
Categories
Short description:
Vanishing Bone unravels the mystery of a totally novel disease which causes the massive destruction of bone in individuals with total hip implants. Although initially considered 'rare,' at its peak the disease affected over a million patients. This book takes readers through a detective adventure in contemporary medical science, identifying the cause of the disease the body's reaction to tiny wear particles from the prostheses, followed by the complex process of affecting its cure, the invention of a unique, wear-resistant plastic.
MoreLong description:
When dozens of holes appeared in a patient's femur alongside his hip prosthesis, experts were baffled as such a phenomenon had never been seen before. Over the first four decades of total hip surgery, the severe bone destruction multiplied, crippling many thousands of patients. Eventually identified as "periprosthetic osteolysis," this devastating disease affected over 1 million patients and was the leading cause of failure in total hip surgery. While total hip surgery dramatically reversed severe arthritis of the hip, the same operation simultaneously created a relentless 'particle generator' in the body. Ironically, in the effort to do good, doctors were simultaneously doing major harm.
Vanishing Bone: Conquering a Stealth Disease Caused by Total Hip Replacements takes readers on a detective adventure in contemporary medical science, from the identification of the cause of the disease through the complex process of affecting its cure. Dr. William H. Harris and his colleagues played an important role in solving the mystery of this disease, pointing to its molecular biology, recognizing the unusual wear of the prostheses, and ultimately developing a new material for use in the manufacture of hip implants. With more than 6 million people walking on this stable, low-wear material, the disease has been virtually eliminated among those with total hip replacements worldwide. Diseases are rarely observed, revealed, and eliminated in one lifetime. Vanishing Bone tells the captivating story of one such disease through an engaging account of scientific and medical innovation.
The purpose is to artfully recreate the evolution of the tackling of a medical problem, prosthetic osteolysis...This is a dynamic, well-written book. It is written more for the lay person, but medical workers will love it as well. It is an essential book not only for a medical library, but also for every library and bookstore.
Table of Contents:
Part I. Astonishing Discoveries
Chapter 1: The Game is Afoot!
Chapter 2: The Cart Before the Horse
Chapter 3: Uniquely Creative, but Dangerous
Chapter 4: The First Real Breakthrough
Chapter 5: Meanwhile, Back at the Ranch---
Chapter 6: Is It Really Cement Disease?
Chapter 7: An Unexpected First Step
Chapter 8: Flying Blind
Chapter 9: The Gamble Pays Off
Chapter 10: Success at Last!
Part II. Final Hurdles
Chapter 11: Terra Incognita: Here Be Dragons
Chapter 12: Suddenly, to the FDA
Chapter 13: A Regrettable Diversion
Chapter 14: Unforeseen Complications
Chapter 15: Panic
Chapter 16: Ubiquitous Success
Chapter 17: Reprise: The Reward of the Clinician-Scientist
Part III. Appendix
Further Reading
Timeline of Key Events
About the Author
