The Neuropathology of Schizophrenia
Progress and Interpretation
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Product details:
- Publisher OUP Oxford
- Date of Publication 24 August 2000
- Number of Volumes laminated boards
- ISBN 9780192629074
- Binding Hardback
- No. of pages386 pages
- Size 248x173x25 mm
- Weight 883 g
- Language English
- Illustrations numerous line figures and 3 halftones 0
Categories
Short description:
What is schizophrenia? This is one of the most controversial questions in psychiatry and mental health research; however, in the last twenty years, there have been significant advances in our understanding of the topic. This book provides a balanced, comprehensive and up-to-date overview of the neuropathology of schizophrenia and its interpretation, covering the latest evidence derived from all fields of research, from brain scans to microscopy. The authors include many of the foremost international authorities in this rapidly developing field.
MoreLong description:
The neuropathology of schizophrenia is one of the most controversial areas of research in psychiatry; however, in the last twenty years, there have been significant advances in our understanding of the topic. This book provides a much needed, balanced, comprehensive and up-to-date overview of this rapidly moving field. It starts by describing the findings derived from new imaging techniques and histological studies, focusing specifically on the morphology, arrangement and connectivity of the neurons making up the cortical cytoarchitecture, a feature thought to be central to understanding the pathology. This is followed by critical appraisal of the various interpretations placed upon these findings, such as the neurodevelopmental hypothesis. Finally, there are chapters considering the conceptual and methodological problems affecting the subject. This is a timely and unique book on this classic and controversial issue, with contributions from many of the leading international experts in the field.
"This is a gem of a book. It is up to date, well written and literally brims with carefully thought out discussions and summaries of the current 'facts' concerning the neuropathology of schizophrenia . . . I do not hesitate to recommend this book to anyone even remotely interested in the neuropathology of schizophrenia. The book contains excellent reviews of the topic and a wealth of ideas for future work."
Table of Contents:
Introduction
Structural imaging findings and macroscopic pathology
Hippocampal pathology
Cortical pathology: a new generation of quantitative microscopic findings
Synaptic pathology
Gliosis and its implications for the disease process
Cerebral asymmetry
Functional imaging and neural circuitry in schizophrenia
Neuropathology and the neurodevelopmental model
Cortical development and schizophrenia
The organization of cortical circuitry
Perspectives from other diseases and lesions
Animal models of schizophrenia
A sceptical view of the neuropathology of schizophrenia
Methodological issues
Neuropathological consequences of schizophrenia treatments
