Sulfonamides: X-Ray Structures and Biological Studies
A new approach towards Biologically Active Compounds
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19 139 Ft (18 228 Ft + 5% VAT)
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19 139 Ft
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Product details:
- Edition number Aufl.
- Publisher LAP Lambert Academic Publishing
- Date of Publication 1 January 2012
- Number of Volumes .
- ISBN 9783659155314
- Binding Paperback
- No. of pages104 pages
- Language English 0
Categories
Long description:
The use of antibiotics in the treatment of various infections of humans caused by microbes has been a great success. Over the past years there has been an increase in the resistance of microorganisms against a large number of drugs. Keeping in view the biological activity and medicinal importance of sulfonamides, new sulfonamides are being synthesized. This book describes the synthesis of N-benzyl-4-methylbenzenesulfonamide, its N-alkylated derivatives and evaluation of their anti-microbial activity. N-benzyl-4- methylbenzene sulfonamide was synthesized by the condensation of benzyl amine with p-toluene benzenesulfonylchloride. The solvent used for this reaction was water.N-alkylated derivatives were prepared by reacting N-benzyl-4-methylbenzenesulfonamide with different alkylating agents and sodium hydride using DMF as solvent. The synthesized compounds were characterized by different techniques like X-ray crystallography, FT-IR, Elemental analyzer and melting point. Evaluation of anti-microbial activity was carried out by employing deep well method against different bacterial strains.The synthesized compounds exhibited appreciable anti-microbial activity.
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