Strategic Disconnections in Retrosynthetic Analysis from Pattern Recognition
An Applied Approach
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Product details:
- Publisher Elsevier Science
- Date of Publication 1 November 2025
- ISBN 9780443365423
- Binding Paperback
- No. of pages416 pages
- Size 276x215 mm
- Language English 700
Categories
Long description:
Strategic Disconnections in Retrosynthetic Analysis from Pattern Recognition: An Applied Approach introduces retrosynthetic analysis through strategic disconnection methods. It prioritizes disconnections of general structures characterized by specific functionalization patterns or structural motifs like stereogenic centers or bicyclic frameworks. Numerous examples from carefully selected literature illustrate each strategic disconnection, organized by functional or structural pattern, selected disconnection, and polar, radical, or concerted reaction pathways. Developing a deep understanding of these examples enhances 3D visualization skills, critical reasoning, and expertise in synthetic strategies.
The book offers insights into advancements in organic synthesis over the last 50 years, with cases of varying complexity from curated literature. Readers can focus on examples that align with their interests or lab work, each case referenced for easy access to primary information. It is ideal for graduate and postdoc students in organic chemistry and synthesis and researchers in industry. Advanced undergraduate students with a solid organic chemistry foundation may also find it beneficial.
Table of Contents:
1. Chemical synthesis as design and construction of molecular architectures: A brief history.
2. Organic Synthesis: Basic concepts, definitions, and classification of synthetic steps
3. Retrosynthetic Analysis, Glossary, and Operating Instructions directed to the synthesis of alkanes and of ether-type linkages
4. One-Group Disconnections: Target molecules containing one carbon-heteroatom bond
5. One-group disconnections: Target molecules containing one carbon-carbon multiple bond
6. Two-group disconnections: 1,3-Bifunctional compounds containing two carbon-heteroatom bonds (diones, aldols, etc.). FS = 3
7. Two-group disconnections: Bifunctional compounds containing two carbon-heteroatom bonds (diones, ketols, etc.) with FS = 2, 4, and 5
8. Two-group disconnections: Bifunctional compounds containing two carbon-carbon double or triple bonds (dienes, diynes, enynes)
9. Two-group disconnections: Target molecules containing one carbon-heteratom bond and one carbon-carbon multiple bond
10. Topology-guided retrosynthetic analysis
11. Ring-guided retrosynthetic analysis of cyclic compounds
12. Chirality-guided retrosynthetic analysis
13. One-pot multistep reactions
14. Organic Synthesis in the 21st Century: The new environment in which organic synthesis is expanding its reach
