Stimulant Drugs and ADHD
Basic and Clinical Neuroscience
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Product details:
- Publisher OUP USA
- Date of Publication 21 December 2000
- ISBN 9780195133714
- Binding Hardback
- No. of pages424 pages
- Size 238x164x26 mm
- Weight 680 g
- Language English
- Illustrations black and white photographs and line figures 0
Categories
Short description:
Stimulant drugs are widely used in the treatment of ADHD in children and adults, yet their mechanism of action have been poorly understood. This volume is the first to integrate advances in the basic and clinical neurosciences in order to shed new light on this important question. The chapter topics span basic research into the neuroanatomy, neurophysiology and neuropsychology of catecholamines, animal models of ADHD, and clinical studies of neuroimaging, genetics, pharmacokinetics and pharmacodynamics, and the cognitive pharmacology of stimulants. The result is a careful, comprehensive, and insightful synthesis by a group of well-known scientists that significantly advances our understanding of stimulant effects and charts a course for future research.
MoreLong description:
Stimulant drugs are widely used in the treatment of ADHD in children and adults. Hundreds of studies over the past 60 years have demonstrated their effectiveness in improving attention span, increasing impulse control, and reducing hyperactivity and restlessness. Despite widespread interest in these compounds, however, their mechanisms of action in the central nervous system have remained poorly understood. Recent advances in the basic and clinical neurosciences now afford the possibility of elucidating these mechanisms. The current volume is the first to bring this expanding knowledge to bear on the central question of why and how stimulants exert their therapeutic effects. The result is a careful, comprehensive, and insightful integration of material by well-known scientists that significantly advances our understanding of stimulant effects and charts a course for future research. Part I presents a comprehensive description of the clinical features of ADHD and the clinical repsonse to stimulants. Part II details the cortical and subcortical neuroanatomy and functional neurophysiology of dopamine and norepinephrine systems with respect to the regulation of attention, arousal, activity, and impulse control on the basis of animal studies. Part III is devoted to clinical research, including recent studies of neuroimaging, genetics, pharmacodynamic and pharmacokinetic properties of stimulants, effects on cognitive functions, neurophysiological effects in humans with and without ADHD and in non-human primates, and comparison of stimulants and non-stimulants in the treatment of ADHD. Part IV is a masterful synthesis that presents alternative models of stimulant drug action and generates key hypotheses for continued research. The volume will be of keen interest to researchers and clinicians in psychiatry, psychology, and neurology, neuroscientists studying stimulants, and those persuing development of new drugs to treat ADHD.
MoreTable of Contents:
Part I: Phenomenology
Attention-Deficit/Hyperactivity Disorder: Clinical Features
Clinical Psychopharmacology of Stimulant Medication in ADHD
Part II: Basic Neuroscience
Introduction to Part II
The Catecholamine Innervation of Primate Cerebral Cortex
Stimulant Effects on Striatal and Cortical Dopamine Systems Involved in Reward-Related Behavior and Impulsivity
Psychostimulant Actions on Dopamine and Limbic System Function: Relevance to the Pathophysiology and Treatment of ADHD
Arousal- and Attention-Related Actions of the Locus Coeruleus-Noradrenergic: Potential Involvement in the Therapeutic Actions of Amphetamine-Like Stimulants
Dopaminergic and Noradrenergic Influences on Cognitive Functions Mediated by Prefrontal Cortex
A Review of Rodent Models of ADHD
The Spontaneously Hypertensive Rat as a Model of ADHD
Part III: Clinical Neuroscience
Introduction to Part III
Neuroimaging Studies of ADHD
Pharmacokinetic and Pharmacodynamic Properties of methylphenidate in Humans
The Cognitive Pharmacology of Stimulants in Children with ADHD
Comparative Psychopharmacology of Methylphenidate and Related Drugs in Human Volunteers, Patients w/ ADHD and Experimental Animals
Comparing the Effects of Stimulant and Non-Stimulant Agents on Catecholamine Function: Implications fot Theories of ADHD
Part IV: Integration
The Neuroscience of Stimulant Drug Action: Implications for ADHD
The Behavior of Children Recieving Benzedrine
