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  • Statistical Theory and Methods for Evolutionary Genomics

    Statistical Theory and Methods for Evolutionary Genomics by Gu, Xun;

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    Product details:

    • Publisher OUP Oxford
    • Date of Publication 4 November 2010

    • ISBN 9780199213269
    • Binding Hardback
    • No. of pages272 pages
    • Size 248x177x19 mm
    • Weight 706 g
    • Language English
    • Illustrations 60 black and white illustrations
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    Short description:

    Summarises the statistical framework of evolutionary genomics, and illustrates how statistical modelling and testing can enhance our understanding of functional genomic evolution.

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    Long description:

    Evolutionary genomics is a relatively new research field with the ultimate goal of understanding the underlying evolutionary and genetic mechanisms for the emergence of genome complexity under changing environments. It stems from an integration of high throughput data from functional genomics, statistical modelling and bioinformatics, and the procedure of phylogeny-based analysis.

    Statistical Theory and Methods for Evolutionary Genomics summarises the statistical framework of evolutionary genomics, and illustrates how statistical modelling and testing can enhance our understanding of functional genomic evolution. The book reviews the recent developments in methodology from an evolutionary perspective of genome function, and incorporates substantial examples from high throughput data in model organisms. In addition to phylogeny-based functional analysis of DNA sequences, the author includes extensive discussion on how new types of functional genomic data (e.g. microarray) can provide exciting new insights into the evolution of genome function, which can lead in turn to an understanding of the emergence of genome complexity during evolution.

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    Table of Contents:

    Preface
    Basics in Molecular Evolution
    Basics in Bioinformatics and Statistics
    Functional Divergence after Gene Duplication: Statistical Modeling
    Functional Divergence after Gene Duplication: Applications and Others
    Phylogenomic Expression Analysis between Duplicate Genes
    Expression between Duplicate Genes: Genome-Wide Analysis
    Tissue-Driven Hypothesis of Genomic Evolution
    Gene Pleiotropy and Evolution of Protein Sequence
    Modeling the Genomic Evolution of Gene Contents
    Advanced Topics in Systems Biology and Network Evolution
    References
    Index

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