Scleroderma by Varga, John; Denton, Christopher P.; Wigley, Fredrick M.;

Short description:

This essential resource presents the most up-to-date information on scleroderma. A clear and concise synthesis of current concepts in pathogenesis and modern approaches to management, this book is comprised of the authoritative work of international experts. With an integrated multidisciplinary approach to comprehensive care, this book is easily accessible for health care professionals in many fields. It is a valuable resource for rheumatologists, pulmonologists, cardiologists, gastroenterologists, nephrologists and all those involved in the care of scleroderma patients.

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Long description:

This essential resource presents the most up-to-date information on scleroderma. A clear and concise synthesis of current concepts in pathogenesis and modern approaches to management, this book is comprised of the authoritative work of international experts. With an integrated multidisciplinary approach to comprehensive care, this book is easily accessible for health care professionals in many fields. It is a valuable resource for rheumatologists, pulmonologists, cardiologists, gastroenterologists, nephrologists and all those involved in the care of scleroderma patients.

From the reviews:

?This is a very comprehensive summary of the various aspects of scleroderma, one of the most complex and challenging autoimmune disorders to diagnose and treat. ? a valuable resource not only for practicing rheumatologists, but also for any physicians who treat scleroderma patients, including gastroenterologists, nephrologists, primary care doctors, and residents. ? good number of illustrations and graphs make the subject more interesting and easier to comprehend. ? The authors have done an incredible job summarizing all the recent research and advances in this area.? (Saba Beg, Doody?s Book Reviews, January, 2014)

?Scleroderma: From Pathogenesis to Comprehensive Management emphasises the multidisciplinary approach to comprehensive care of the scleroderma patient. The book serves as a valuable management guide and scientific review for both the ?sclerodermaologist?/clinician and the budding researcher seeking in-depth and authoritative discussions on all aspects of scleroderma. The book is recommended to any clinician who participates in the care of our patients with this complex, yet fascinating syndrome.? (R. Saggar, European Respiratory Review, Vol. 21 (126), December, 2012)

?This book integrates the latest developments in scleroderma in terms of understanding its pathophysiology and management. The purpose is to provide an ultimate source that integrates historical management, current pathophysiology, and the possible future of better therapy. ? The book is written for rheumatologists.? (Hyon Ju Park, Doody?s Review Service, March, 2012)

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Table of Contents:

Foreword.- Preface.- Historical Perspective.-Therapeutic evolution: a professor?s view.- Overview: Epidemiology, Genetics and Classification.-Epidemiology and Environmental Risk Factors.- Genetic Factors.- Disease Subsets in Clinical Practice.-Evolving Concepts of Diagnosis and Classification.- Disease Classification using Molecular Signatures.-Localized Scleroderma.- Juvenile Systemic Scleroderma.-Scleroderma Mimics.- Localized Forms of Scleroderma in Adults.-Overview: Integrated Pathogenesis.- Immunological Mechanisms.-Innate Immunity.- Autoantibodies in Pathogenesis.- The Clinical Aspects of Autoantibodies.- Mechanisms of Vascular Disease.-Vascular Biomarkers.- Mechanisms of Fibrosis.- Fibrosis: Insights from the stiff skin syndrome.- Biomarkers of Fibrosis.- Overview of Animal Models.-Overview: Cardiovascular Manifestations and Management.-Raynaud Phenomenon.-Nailfold Capillaroscopy.- Systemic Vascular Disease.- Scleroderma Renal Crisis.- Cardiac Involvement.-Erectile Dysfunction.-Overview: Pulmonary manifestations and management.-Clinical Assessment of Lung Disease.- Computerized Tomography of Interstitial Lung Disease.-Treatment of interstitial lung disease.-Clinical Assessment of Pulmonary Hypertension.-Treatment of Pulmonary Hypertension.- Complex Challenges of Pulmonary Hypertension.- Overview: Gastrointestinal Manifestations and Management.- Upper Gastrointestinal Tract.-Small and Large Intestinal Involvement.-Evaluation and Management of Skin Disease.-Skeletal Muscle Involvement.-  Tendons, Joints and Bone.- Pregnancy.-Overlooked Manifestations.- Principles of Management.-Immunomodulatory Therapies.-Cell-Based Therapies.- Investigative Approaches to Drug Therapy.-Complementary and alternate medicine approaches.-Physical and occupational therapy.- Evaluation and Management of Psychosocial Issues.-Issues in Clinical Trial Design.- Measuring Disease Activity.- Patient Reported Outcomes. 

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