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  • Risk Assessment for Human Metal Exposures: Mode of Action and Kinetic Approaches

    Risk Assessment for Human Metal Exposures by Nordberg, Gunnar F.; Fowler, Bruce A.;

    Mode of Action and Kinetic Approaches

      • GET 10% OFF

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      • Publisher's listprice EUR 114.00
      • The price is estimated because at the time of ordering we do not know what conversion rates will apply to HUF / product currency when the book arrives. In case HUF is weaker, the price increases slightly, in case HUF is stronger, the price goes lower slightly.

        47 281 Ft (45 030 Ft + 5% VAT)
      • Discount 10% (cc. 4 728 Ft off)
      • Discounted price 42 553 Ft (40 527 Ft + 5% VAT)

    47 281 Ft

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    Product details:

    • Publisher Elsevier Science
    • Date of Publication 23 August 2018

    • ISBN 9780128042274
    • Binding Paperback
    • No. of pages348 pages
    • Size 229x152 mm
    • Weight 500 g
    • Language English
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    Long description:

    Risk Assessment for Human Metal Exposures: Mode of Action and Kinetic Approaches examines the current principles of risk assessment in human metal exposures, with a focus on Mode of Action(MOA), Toxicokinetic and Toxicodynamic (TKTD) considerations, and computer models. Derived from the highly respected Handbook on the Toxicology of Metals, Fourth Edition (2014), the book summarizes principles and methods and provides examples of how MOA -TKTD can be used. In addition, it presents tactics on how information generated by such methods can be confirmed by epidemiological data. Furthermore, it demonstrates how epidemiological data can be confirmed and evaluated by the examined models and considerations.

    This resource uniquely integrates several important topics, such as risk assessment, characterization, management and communication-the classic risk assessment paradigm-with mode of action, TKTD, and epidemiology, all topics related to human exposure. Written by pioneers in the field, this book is an essential reference for researchers, students and technicians in toxicology and risk assessment.

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    Table of Contents:

    1. Metal Exposures and Human Health - Historical development, Current Importance and Toxicological Concepts for Prevention2. Exposure, Internal Dose and Toxicokinetics (TK).3. Biomonitoring, Mode of Action (MOA), Target Dose and Adverse Outcome Pathways (AOPs)4. Hazard Identification and Assessment5. Dose-Effect and Dose-Response Assessment6. Dose-Response for Essential Metals and the Evaluation of Mixed Exposures7. Applied Risk Assessment, Hazard Assessment and Risk Management8. Examples of Risk Assessments of Human Metal Exposures and the need for MOA TKTD

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