Receptor and Ion-Channel Trafficking
Cell Biology of Ligand-Gated and Voltage-Sensitive Ion Channels
Series: Molecular and Cellular Neurobiology Series;
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120 198 Ft
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Product details:
- Publisher OUP Oxford
- Date of Publication 22 August 2002
- ISBN 9780192632241
- Binding Hardback
- No. of pages236 pages
- Size 248x174x18 mm
- Weight 646 g
- Language English
- Illustrations numerous halftones and figures 0
Categories
Short description:
This book reviews the recent advances in our understanding of the the molecular and cellular mechanisms regulating the targeted movement (trafficking) of receptors and ion channels in neurones - mechanisms fundamental to synaptic function.
MoreLong description:
A volume in the Molecular and Cellular Neurobiology series.
This book reviews the recent advances in our understanding of the molecular and cellular mechanisms that control the assembly, transport, targeting and anchoring of the protein complexes making up the most important ion channels and receptor families, fundamental to synaptic function. Improved understanding of these processes is expected to reveal novel therapeutic targets relevant to a range of disease states.
The first section of the book contains three chapters dealing with cation channels and provides an accessible, succinct and comprehensive account of what is known about the structures and the assembly and targeting of these multimeric proteins. The focus of the book then moves on to cover ligand-gated ion channels with two chapters on acetylcholine receptors. The final section of the book contains four chapters covering the excitatory and inhibitory amino acid receptors.
Receptor and Ion-Channel Trafficking provides an integrated overview of the significant recent advances in the field of molecular neurobiology and will be essential reading for all researchers in neuroscience, neurobiology, biochemistry, cellular and molecular biology.
"The editors and authors have done an excellent job ... Moss and Henley make a valuable contribution by highlighting major advances in the membrane trafficking of specific neurotransmitter receptors and ion channels ... this book is a most interesting and thought-provoking read." Nature Cell Biology
Table of Contents:
Ion Channels
Voltage-gated sodium channels
The assembly and targeting of potassium channels
Assembly and targeting of voltage-dependent calcium channels
Acetylcholine Receptors
Targeting of acetylcholine receptors to the postsynaptic endplate of the nerve-muscle synapse
Assembly and targeting of neuronal nicotinic acetylcholine receptors
Amino Acid Receptors
AMPA/kainate receptors
NMDA receptor targeting
Structure, assembly and targeting of glycine receptors
GABAA and GABAC receptors: regulation of assembly, localization, clustering and turnover
Receptor and Ion-Channel Trafficking: Cell Biology of Ligand-Gated and Voltage-Sensitive Ion Channels
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