Rapidly Progressive Glomerulonephritis
Series: Oxford Clinical Nephrology Series;
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Product details:
- Publisher OUP Oxford
- Date of Publication 19 March 1998
- ISBN 9780192626363
- Binding Hardback
- No. of pages290 pages
- Size 248x173x21 mm
- Weight 700 g
- Language English
- Illustrations black and white photographs, line figures and tables 0
Categories
Short description:
Rapidly Progressive Glomerulonephritis (RPGN) is the term used to describe severe inflammation of the glomeruli (filtering units) of the kidney. This may be the result of various diseases, and generally leads to the development of kidney failure within a few months, requiring dialysis or transplantation. Fortunately, many cases improve when treated with the appropriate drugs. This book outlines the major types of RPGN, and describes what is known of the underlying disease mechanisms. Most of these are due to an imbalance in the immune system, such that it attacks the patient's own kidneys - this is known as "autoimmunity". Knowledge of these immune abnormalities helps in the diagnosis and treatment of RPGN. The rapid advances in this field should offer hope to an increasing number of patients.
MoreLong description:
Rapidly Progressive Glomerulonephritis is one of the most exciting areas in renal medicine. The disease usually presents acutely, and leads to end stage renal failure in weeks or months if untreated. However, appropriate immunosuppressive therapy can dramatically improve the prognosis in many cases, such that renal failure is avoided. It is now clear that various immunopathological processes are involved, and that an accurate diagnosis is of value in guiding management. This volume aims to bring together current knowledge of both scientific and clinical aspects of RPN. Recent advances in the immunology, inflammatory mechanisms and pathology of RPGN are discussed. This is followed by consideration of the major causes of RPGN, which include Goodpasture's disease, primary systemic vasculitis and systemic lupus erythematosus. RPGN secondary to other renal and systemic diseases, and RPGN in children are also described. Finally, new approaches to treatment are reviewed. Although certain of these areas are covered in the larger textbooks of renal medicine, our aim is to provide a current overview of RPGN, in a concise volume. This should be of particular interest to nephrologists and general physicians, including those in training, but may also be of value to pathologists, immunologists, and other studying the mechanisms of renal disease. We hope that this volume will help them in the management of patients with RPGN, or in planning their research into this condition.
'...This book does not disappoint the reader. It is carefully crafted to deal with all aspects of RPGN in a masterly way, easily read and satisfying to the professional nephrologist...This book should be on the shelf of every nephrologist, and this reviewer advises them to buy it.'
