Practical Guide to Hereditary Breast and Ovarian Cancer III
Annual Meeting of the Japanese Organization of Hereditary Breast and Ovarian Cancer 2023
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Product details:
- Publisher Springer Nature Singapore
- Date of Publication 28 October 2025
- Number of Volumes 1 pieces, Book
- ISBN 9789819667789
- Binding Hardback
- No. of pages157 pages
- Size 235x155 mm
- Language English
- Illustrations II, 157 p. 19 illus., 14 illus. in color. Illustrations, black & white 700
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Long description:
This book is a curated collection of research and perspectives of hereditary breast and ovarian cancers (HBOC). With contributions from leading experts in the field, the book provides a valuable resource for a holistic view of the genetic basis, clinical developments and societal implications of these critical diseases. Hence it bridges the gap between science and real-world applications and aims to contribute to empower clinicians? treatment decisions in HBOC care.
The practice for HBOC has been rapidly increasing due to the clinical development of poly(ADP-ribose) polymerase inhibitors and the spread of companion diagnostics, and it has been changing drastically with the insurance coverage of a part of HBOC treatment in Japan. This volume is based on the best-chosen works presented at JOHBOC and a special chapter delivers a study based on the Society?s extensive database of Japanese HBOC patients, presenting novel evidence for further advancement in the field.
Practical Guide to Hereditary Breast and Ovarian Cancer III - Annual Meeting of the JOHBOC is realized in the background of the remarkable changes in social conditions surrounding HBOC practice and the editors and the authors aim to contribute to the equalization and the widespread of HBOC practice in Japan by sharing the latest information on HBOC practice with medical practitioners, making it useful for their future treatment through this book.
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Table of Contents:
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Genetic Analysis of Inherited Breast and Ovarian Cancer: from Gene Discovery to Precision Medicine and Public Health.- Mechanisms underlying the registance to platinum and PARP inhibitors in BRCA1/2-mutated tumors.- Repair for estrogen-induced DNA damage requires BRCA1.- Update of Radiation Sensitivity in HBOC.- What determines the difference of age at onset?.- Issues on HBOC and PGT-M in Japan.- Comments on the HBOC guideline for PGT-M.- Medical cares handling social response to ""hereditability"".- Social challenges of PGT-M for HBOC and their recognition by medical staff.- Statement from a patient.- JOHBOC registration data up to date 2023.
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