Pharmacology of Cytokines
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Product details:
- Publisher OUP Oxford
- Date of Publication 7 September 2000
- ISBN 9780198500421
- Binding Paperback
- No. of pages344 pages
- Size 240x168x18 mm
- Weight 565 g
- Language English
- Illustrations 1 plate, 42 line figures 0
Categories
Short description:
Cytokines are the 'words' of immunity, serving as mediators within and outside the immune system. There is tremendous interest in their exploitation as therapeutic tools in diverse human diseases and considerable effort has been made to understand and utilize their pharmacology. This book examines this pharmacology, from development and characterization of simple chemicals and their mechanism of action to the use of biotechnology- based approaches. The book puts cytokines and their pharmacology in context and examines their involvement in individual organ-disease systems.
MoreLong description:
Cytokines are polypeptide mediators which act as communication signals among cells of the immune system as well as among other cells and tissues in the body. They are a heterogeneous and complex group and include interferons, tumor necrosis factor and chemokines. They play a key role in homeostasis and in host defence and are involved in such inflammatory and autoimmune diseases such as rheumatoid arthritis as well as infectious diseases such as HIV infection and septic shock. Modulation of the production and action of cytokines, as well as their exploitation as therapeutic agents, has been the object of intense and competitive research. This book overviews the field of cytokine research and describes the various approaches that have been taken to develop the pharmacology of these novel mediators. The pharmacology of cytokines is an exploding area which is entering the clinical arena. The book, in the framework of the immunobiology of cytokines, examines the interactions with the cytokine system of a variety of compounds ranging from simple synthetic chemicals to biotechnological products . In addition to examining individual agents and approaches, the book examines the pathophysiology of individual body systems and analysis specific contexts for the pathophysiology of these mediators as well as pharmacological approaches for their control.
"This book provides a 'breath of fresh air' in an otherwise complicated area of Immunology. In conclusion the authors have managed to produce a concise, well researched and well organised book, which lives up to its aims, in doing so it provides a useful review of research efforts in cytokine pharmacology, as such the book is suitable for clinicians, research scientists and students of Immunology interested in cytokine pharmacology." Immunology News
Table of Contents:
Preface
Cytokines: a world apart
Part I: Pharmacology
Inhibitors of cytokine production and action
Inhibitors of cytokine processing
Receptor antagonists
Antibodies and soluble receptors
Anti-inflammatory/immunosupressive cytokines
Part II: Pharmacology in a context
Nervous system
Cardiovascular system
Cancer
Liver and lung
Skin
Sepsis
Appendix: Interferon Beta
