Paraneoplastic Syndromes
Series: Contemporary Neurology Series; 79;
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Product details:
- Publisher OUP USA
- Date of Publication 8 September 2011
- ISBN 9780199772735
- Binding Hardback
- No. of pages498 pages
- Size 188x259x30 mm
- Weight 1409 g
- Language English
- Illustrations 254 illustrations 0
Categories
Short description:
This comprehensive monograph on paraneoplastic syndromes discusses the clinical symptomatology, the diagnosis, the associated autoantibodies and the treatment of individual paraneoplastic syndromes. It emphasizes both the clinical experience of the office and provides an extensive review of the literature.
MoreLong description:
Paraneoplastic syndromes, defined in this book as "disorders caused by cancer, but not a direct result of cancer invasion of the affected organ or tissue", once believed to be rare and esoteric neurologic disorders have assumed increasing importance as an explanation of neurologic and other symptoms in patients suffered from occult or controllable cancers. This book attempts a comprehensive review of paraneoplastic syndromes from considering both clinical and pathophysiologic aspects. The book is divided into 4 sections: The first is an overview, classifying the disorders, describing a clinical approach to the diagnosis and treatment of paraneoplastic syndromes in general and identifying their pathogenesis. The second section discusses the clinical findings and treatment of individual paraneoplastic syndromes with chapters dedicated to each of the neurologic syndromes and a chapter discussing nonneurologic syndromes such as endocrine, cutaneous, and rheumatologic paraneoplastic disorders. The third section discusses autoantibodies that characterize individual paraneoplastic syndromes. The final section discusses the paraneoplastic syndromes associated with individual cancers.
MoreTable of Contents:
Contents
SECTION 1 OVERVIEW
1. HISTORY
DEFINITIONS
CLASSIFICATION
HISTORY
Pathogenesis
EPIDEMIOLOGY
IMPORTANCE
2. CLINICAL FINDINGS, TREATMENT AND PROGNOSIS
INTRODUCTION
CLINICAL APPROACH
The Patient without Known Cancer The Patient with Known Cancer
CLUES TO DIAGNOSIS
Clinical Findings Laboratory Investigation
PATHOLOGY
TREATMENT
Plasma Exchange (Plasmapheresis) Intravenous Immunoglobulin
Rituximab Cyclophosphamide Corticosteroids Human Chorionic Gonadotropin Recommendations
PROGNOSIS
3. PATHOGENESIS
INTRODUCTION
HISTORICAL VIEWS
Toxic Substances Competition for Essential Substrate Bullet Opportunistic Infection Immune Mediated
CURRENT CONCEPTS OF PATHOGENESIS
Unresolved Questions Conclusions
ANIMAL MODELS
SECTION 2 CLINICAL SYNDROMES
4. BRAIN (CEREBRUM)
INTRODUCTION
CEREBRAL CORTEX
WHITE MATTER DEMYELINATION
BLOOD VESSELS (VASCULITIS)
HIPPOCAMPUS/LYMBIC ENCEPHALITIS
TASTE
