Nicotine Safety and Toxicity
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37 264 Ft
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Product details:
- Publisher OUP USA
- Date of Publication 29 April 1999
- ISBN 9780195114966
- Binding Hardback
- No. of pages224 pages
- Size 241x162x22 mm
- Weight 544 g
- Language English
- Illustrations numerous tables and graphs 0
Categories
Long description:
Nicotine has been developed as a medication to assist smoking cessation, and is being considered as a possible drug for long-term maintenance of non-smoking. It is also undergoing evaluation as a possible treatment for several medical disorders, including ulcerative colitis, Alzheimer's disease, Parkinson's disease, Tourette's syndrome, attention deficit disorder, spasticity, and sleep apnea. Understanding its safety and toxitity is essential for drug developers, drug regulators, and clinicians making risk/benefit decisions about long-term nicotine therapy. Research on nicotine toxicity is also relevant to ongoing research on tobacco and health aimed at understanding the role of nicotine in contributing to tobacco-induced diseases. This book reviews the current scientific understanding of the safety and toxicity of nicotine. The discussion ranges from chemistry, studies in animals and human experimental research to the results of large clinical trials. Among the topics covered are cardiovascular disease, cancer, reproductive toxicity (including fetal toxicity and Sudden Infant Death Syndrome), behavioral toxicity (including abuse liability and addiction to nicotine medication), and gastrointestinal disease. Finally, contributions explore the risks and benefits of nicotine as a medication. The authors are world-renowned experts on their respective topics. No other book addresses nicotine toxicity in the depth or breadth of this volume. A book on the cutting edge of contemporary public health discourse, Nicotine Safety is an up-to-date and lucid overview of current knowledge on the subject. It will be a necessary addition to the bookshelves of clinicians with an interest in tobacco and health, drug developers and researchers, pharmacologists and toxicologists, public health researchers and policy-makers.
This book is very useful for scientific/clinicians in the nicotine research field, but will also be informative to scientists in associated fields.
Table of Contents:
Nicotine Pharmacology and Addiction
I. Nicotine and Cardiovascular Disease
Cardiovascular Toxicity of Nicotine: Pharmacokinetic and Pharmacodynamic Considerations
Cardiovascular Toxicity of Nicotine in Animals
Cardiovascular Effects of Cigarette Smoke and Snuff
Toxicity of Nicotine Replacement in Patients with Coronary Artery Disease
II. Nicotine and Cancer
The Metabolic Fate of (S)-Nicotine and its Pyrrolic Analog b-nicotyrine
Tobacco-Specific Nitrosamines
Nicotine and Lung Cancer
III. Nicotine and Reproduction
The Impact of Fetal Nicotine Exposure on Nervous System Development and Its Role in Sudden Infant Death Syndrome (SIDS)
Measuring Fetal Exposure to Nicotine
Human Studies of Nicotine Replacement During Pregnancy
IV. Behavioral Toxicity of Nicotine
Abuse Liability of Nicotine
