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  • Neurobiology of Nociceptors

    Neurobiology of Nociceptors by Belmonte, Carlos; Cervero, Fernando;

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      • Publisher's listprice GBP 165.00
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    78 828 Ft

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    Product details:

    • Publisher OUP Oxford
    • Date of Publication 1 August 1996

    • ISBN 9780198523345
    • Binding Hardback
    • No. of pages542 pages
    • Size 251x175x35 mm
    • Weight 1225 g
    • Language English
    • Illustrations halftones, numerous line figures, tables
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    Short description:

    This is the first book devoted to the neurobiology of nociceptors, specialised receptors for pain, which were first described conceptually nearly 100 years ago. Leading researchers have provided a comprehensive overview of the structure of nociceptors, their role in signalling injury, their transduction mechanisms, and changes to these mechanisms which result from nerve injury or regeneration. Neurobiology of Nociceptors will be essential for both researchers and clinicians in the study of pain and pain management.

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    Long description:

    This is the first comprehensive review of all aspects of nociceptor function, including the structure of nociceptor endings, their neurochemistry, and evolutionary considerations. It deals with the functional properties of nociceptors innervating different organs and the biophysical mechanisms underlaying the transduction process in nociceptors. There are sections on how nociceptor function is modified by nerve injury and regeneration and on its physiopathology.

    This is an essential reference for researchers in neuroscience and pharmacology, and clinicians working in pain management.

    a compilation of detailed chapters, which attempts and succeeds as a thorough review of the literature pertaining to nociceptors up to 1995 ... the book is well organized and carefully written and edited so that it remains readable and thought-provoking throughout ... a comprehensive source text that provides appropriately referenced key concepts of contemporary research involving nociceptors, and brings into focus current perspectives for understanding their role in pain perception

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    Table of Contents:

    Preface
    Principles of classification and nomenclature relevant to studies of nociceptive neurones
    Part 1: Basic aspects of nociceptor function
    Pain and the discovery of nociceptors
    Structure of nociceptor 'endings'
    Neurochemistry of cutaneous nociceptors
    Comparative and evolutionary aspects of nociceptor function
    Part 2: Nociceptors and the signalling of injury
    Cutaneous nociceptors
    Corneal nociceptors
    Nociceptors in skeletal muscle and their reaction to pathological tissue changes
    Neurobiology of articular nociceptors
    Visceral nociceptors
    Part 3: Transduction mechanisms and sensitization
    Signal transduction in nociceptors: general principles
    Chemical excitation and sensitization in nociceptors
    Intracellular messengers and signal transduction in nociceptors
    Sensitization of polymodal receptors
    Part 4: Functions of nociceptors
    Functional properties of human cutaneous nociceptors and their role in pain and hyperalgesia
    Neural mechanisms of primary hyperalgesia
    Secondary cutaneous dysaesthesiae
    Efferent function of nociceptors
    Nociceptors and neuroimmune interactions
    Part 5: Nociceptor plasticity
    Development of the nociceptor phenotype: role of nerve growth factor
    Properties of regenerated nociceptor afferents
    Pathophysiology of human nociceptor function

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