Magnetic Resonance in Chemistry and Medicine by Freeman, Ray;

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Product details:

Publisher OUP Oxford
Date of Publication 24 April 2003

ISBN 9780199262250
Binding Paperback
No. of pages290 pages
Size 234x157x17 mm
Weight 455 g
Language English
Illustrations numerous figures and line drawings

Short description:

Magnetic resonance (MR) makes use of tiny radio signals emitted by the nucleus of the atom. There are two important applications -- chemistry, where MR allows us to visualise the architecture of molecules, and medicine, where it provides a clear picture of human anatomy without the need for invasive surgery. This is the first unified treatment of Nuclear Magnetic Resonance (NMR) in chemistry and Magnetic Resonance Imaging (MRI) in medicine, written for a broad non-specialist readership by one of the world's foremost NMR spectroscopists.

Long description:

Magnetic resonance (MR) measures the tiny radio frequency signals emitted by the nucleus of the atom when living or inanimate material is placed in a magnetic field. On the one hand, these signals allow scientists to picture the architecture of molecules too small to be seen under the most powerful microscope, while on the other hand they give medical doctors a detailed picture of the internal structure of the human body without resorting to surgery of any kind. These two applications (high-resolution NMR spectroscopy and the MRI scanner) seem to be worlds apart, but the underlying physical principles are the same, and it makes sense to treat them together. Chemists and clinicians who use magnetic resonance have much to learn about each other's specialities if they are to make the best use of magnetic resonance technology. Many in the medical fraternity will benefit from a general appreciation of how high-resolution NMR has advanced our understanding of human biochemistry, diagnostic medicine, and the search for new drugs. A broad general understanding of magnetic resonance should prove of interest to doctors who make use of the MRI scanner, and to those of their patients who wish to learn more about these daunting machines, even if it is only the question of their own personal safety. At the other end of the spectrum, chemists and biochemists who use high-resolution NMR spectroscopy in their everyday investigations will benefit by broadening their horizons to cover the exciting new developments in MR imaging and in vivo spectroscopy, as one justification for their research is the eventual benefit to health care. Finally, anyone interested in how the human mind works (cognitive neuroscience) will find a chapter devoted to the exciting new developments in functional magnetic resonance imaging of the brain. Each disparate group has something useful to learn from the others. The treatment is pictorial rather than mathematical.

As the exposure of the wider scientific community (and the general public) to these techniques continues to increase, this book should be welcomed as a valuable way of making the basic physics behind them understandable to as wide an audience as possible.

Introduction
Excitation of magnetic resonance
Detection of magnetic resonance
Relaxation
Sensitivity
Resolving power
The Chemical Shift
Spin-spin coupling
Spin Echoes
NMR in solids
Two-dimensional spectroscopy
Magnetic resonance imaging
How safe is magnetic resonance imaging
Magnetic resonance spectroscopy
High-resolution NMR of body fluids
The search for new drugs
Functional imaging of the brain