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Product details:
- Edition number 1
- Publisher OUP Oxford
- Date of Publication 10 August 2018
- ISBN 9780198834359
- Binding Paperback
- No. of pages334 pages
- Size 247x170x18 mm
- Weight 606 g
- Language English 0
Categories
Short description:
Landmark Papers in Pain discusses 83 core examples of novel research and seminal papers that revolutionised Pain Medicine. Leading specialists give detailed commentaries on the significance of literature which stimulated a paradigm shift in therapeutic strategy or acted as a catalyst for improved clinical methods in the field.
MoreLong description:
Pain Medicine, a relatively new specialty, has proven increasingly relevant to medical practitioners in every field. The specialism of pain has emerged over the past 50 years, largely due to the persistence of experts and new medical evidence that points to its necessity. Today, it is a distinct and integral part of global medical practice.
Landmark Papers in Pain offers a comprehensive inventory of over 80 key studies in pain medicine from the last 100 years. Each paper is accompanied by a concise commentary on the significance of the original findings written by an expert in pain. The reviews discuss how the paper influenced the development of the speciality, and how the findings have advanced our global comprehension of pain. Together, the selected papers and reviews chart the growth of an embryonic field into the modern speciality of pain medicine.
Complied by leading specialists in the field, the papers included in this book are significant for any student, researcher, clinical practitioner, or medical historian interested in pain medicine. Organised into eight distinct topics and cross-referenced by topics and author of original paper, the book is comprehensive in its coverage and easy to use. A review of the contemporary and historical research that shaped the speciality of pain, Landmark Papers in Pain is essential reading for all medical practitioners with an interest in pain medicine.
Table of Contents:
Section 1: Historical
Local anaesthetic substitutes for cocaine
Innovative concepts in pain management
Explaining reflex sympathetic dystrophy
The rediscovery of paracetamol
The pharmacology of placebos
Understanding the responsiveness of c-fibres
A new theory of pain
Three determinants of pain
Purinergic nerves: a new type of nerve
Genetic differences in opiate receptors
Endogenous opioids in placebo-induced analgesia
Ethical pain experimentation in conscious animals
Local anaesthetic creams
The backpain revolution
The mechanism of aspirin
Mechanisms of visceral pain in IBS
The effects of morphine on the central nervous system
Opiods in palliative care
Endogenous opioids in the central nervous system
Spinal opioid analgesia in the rat
Section 2: Firsts
The key role of NGF in inflammatory pain processing
Mapping of neurotrophin receptors on adult sensory neurons
Plasticity in somatic receptive fields after nerve injury
Peripheral neural mechanisms of cutaneous hyperalgesia and heat pain
The Cloning and Characterization of CB1
Deorphanisation of ORL-1/LC132 by reverse pharmacology in two landmark studies
The capsaicin receptor
Vanilloid receptor 1 in inflammatory thermal hyperalgesia
A signature of pain in the brain
Cytokines as central to peripheral sensitisation and hyperalgesia
Endogenous opioids mediate stress-induced analgesia
The first crystal structure of an iGluR ligand-binding core
Control of pain initiation by endogenous cannabinoids
Peripheral Analgesia involves Cannabinoid Receptors
Glia: a new pain target
The challenges of animal models of pain
Mechanisms of bone cancer pain
Molecular Structure of the Mu-Opioid Receptor
Milestone Effect of DNIC in our Understanding of Pain
Original description of central sensitisation
Molecular basis for Placebo effect
Section 3: Science
Early discussions on a mechanistic approach to pain
Plasticity: a key concept in pain
The importance of descending modulatory pain systems
Nocebo and its importance in clinical practice
Mechanisms of Action of Acetaminophen for Pain Treatment
Making the link from central sensitization to clinical pain
Section 4: Clinical
Proof of concept: epidural morphine
The Definition of Fibromyalgia
The advent of PCA for post operative analgesia
Undertreatment of pain with metastatic cancer
Faces scales in paediatric pain assessment
Epidural block and phantom limb pain
Clarifying the concept of Breakthrough pain
Section 5: Mechanisms
Paediatric pain epidemiology
Recognising the importance of HIV disease and pain
Fast acting fentanyl for breakthrough pain
The additive analgesia of adrenaline in epidural blockade
What is the clinical relevance of the Likert scale for pain
Post operative pain: assessing the standards
Opioid induced hyperalgesia
CRPS epidemiology
Seminal paper on epidemiology of cancer pain
Endoscopic ultrasound guided coeliac plexus block
Section 6: Neuropathic
Autotomy: an early neuropathic pain model
Risk factors for post amputation pain
Chronic constriction injury (CCI) model of neuropathic pain
Antineuropathic medication combination therapy
RCT evidence for gabapentin in post herpetic neuralgia
Identification of the target of gabapentinoid action in neuropathic pain
Recognition of the importance of Neuropathic pain epidemiology
Botox analgesia for neuropathic pain
DNIC and prediction of chronic post surgical pain
Pregabalin in the reduction of chronic post knee surgery chronic pain
Multidisciplinary Cognitive Behavioural Treatment for Chronic Pain
Disability in Chronic Low Back Pain
Section 7: Psychosocial
The Understanding of Social Effects in Pain
Section 8: Genetics
Congenital insensitivity to pain
Polymorphic CYP2D6 as the Responsible Enzyme of Activation
COMT genotypes in pain responses
The link between NaV1.7 mutation and erythromelalgia
COMT and morphine use in cancer pain
Pioneering use of gene therapy for pain
