Long description:

Ion channels are membrane proteins that act as gated pathways for the movement of ions across cell membranes. They play essential roles in the physiology of all cells. In recent years, an ever-increasing number of human and animal diseases have been found to result from defects in ion channel function. Most of these diseases arise from mutations in the genes encoding ion channel proteins, and they are now referred to as the channelopathies.

Ion Channels and Disease provides an informative and up-to-date account of our present understanding of ion channels and the molecular basis of ion channel diseases. It includes a basic introduction to the relevant aspects of molecular biology and biophysics and a brief description of the principal methods used to study channelopathies. For each channel, the relationship between its molecular structure and its functional properties is discussed and ways in which genetic mutations produce the disease phenotype are considered.

This book is intended for research workers and clinicians, as well as graduates and advanced undergraduates. The text is clear and lively and assumes little knowledge, yet it takes the reader to frontiers of what is currently known about this most exciting and medically important area of physiology.

Table of Contents:

From Gene to Protein
How Channels Work
Methods for Studying Ion Channels
Voltage-Gated Na⁺ Channels
Voltage-Gated K⁺ Channels
Ca-Activated K⁺ Channels
Inward Rectifier K⁺ Channels
Voltage-Gated Ca²⁺ Channels
Voltage-Gated Cl^- Channels
Cyclic Nucleotide-Gated Channels
CFTR
Epithelia Na⁺ Channels
Ligand-Gated Ca²⁺ Channels
ACh Receptor Channels
Glutamate Receptor Channels
Glycine Receptors
GABA Receptors
Water Channels
Gap Junction Channels
Antibodies to Ion Channels
Ion Channels in Viruses
Ion Channels as Lethal Agents
A Miscellany of Ion Channels
The Last Word