Human Genetics in Latin America
Volume I: Admixture and Human Diseases
Series: The Latin American Studies Book Series;
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Product details:
- Publisher Springer Nature Switzerland
- Date of Publication 28 August 2026
- ISBN 9783032236098
- Binding Hardback
- No. of pages331 pages
- Size 235x155 mm
- Language English
- Illustrations XVII, 331 p. 700
Categories
Long description:
Human Genetics in Latin America is the first volume of a trilogy developed by the Latin American Network of Human Genetics (RELAGH) and the Latin American Academy of Sciences (ACAL) that addresses a major gap in global genomics. The book explores why studying genetic diseases in Latin American populations is both scientifically and medically essential, highlighting the region’s extraordinary genetic diversity shaped by centuries of admixture among Indigenous, European, African, and Asian populations. Through contributions from leading researchers and clinicians, this volume examines population structure, founder effects, rare disorders, and complex diseases such as cancer, diabetes, neurological, and psychiatric conditions. It demonstrates how ancestry and admixture influence disease risk, clinical presentation, and treatment response. By placing Latin America at the center of genetic research, the book offers a timely framework for understanding human disease from a regional perspective with global relevance and for advancing more inclusive, equitable, and effective genomics and precision medicine worldwide.
MoreTable of Contents:
1 Introduction.- 2 Evidence and Impact of Natural Selection in Latin American Populations.- 3 Hemoglobinopathies in Latin America.- 4 Founder Effect on Autosomal Dominant Limb-Girdle Dystrophy D3.- 5 Ancestral Genetic Origins of Huntington Disease and Huntington Disease-like 2 in Venezuela.- 6 Founder Effect and Geographic Isolation as a Frequent Cause of High Prevalence for Rare Diseases.- 7 Mucopolysaccharidosis Type VI and Other Genetic Disorders in a Rural Area of Bahia, Brazil.- 8 Genetic Isolates and Clusters of Genetic Disorders in Latin America.- 9 Common Germline Genetic Variation and Breast Cancer Risk in Women of Latin American Origin.- 10 The Genetics of Type 2 Diabetes in Latinos and Latin Americans.- 11 Genetics of Parkinson’s Disease.- 12 Evolution of the Field of Psychiatric Genetics in Latin America.- 13 Insights into Focal Epilepsies.- 14 Leveraging Polygenic Risk Scores and Genome-Wide Association Studies for Precision Medicine in Admixed Latin American and Caribbean Populations.- 15 Pharmacogenetics and Pharmacogenomics in Latin American Populations.
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