Hematopoietic Stem Cell Transplantation for Neurological Diseases (HSCT), Volume 201 provides the latest information on what has been evaluated as a possible therapeutic tool in severe autoimmune diseases for the last 20 years. In the neurological field, HSCT has been widely investigated for the treatment of multiple sclerosis and evidence is accumulating about its potential use in neuromyelitis optica, stiff person syndrome, myasthenia gravis, and many immune neuropathies. Besides their strong clinical relevance, studies on HSCT in neurological diseases have contributed to new insights on the pathological mechanisms underlying CNS autoimmunity, hence this volume summarizes that research.

Reviews immunological mechanisms of HSCT and CNS autoimmunity
Identifies neurological diseases showing treatment efficacy with HSCT
Includes MS, myasthenia gravis, neuromyelitis optica, and more
Covers early and late side effects of HSCT

Table of Contents:

1. Introduction to HSCT for neurologic diseases
2. Modification of T and B cell-associated immuno-pathological mechanisms in multiple sclerosis by disease modifying therapies: achievements and opportunities
3. The hematopoietic niche and the autoreactive memory in autoimmune disorders
4. The preclinical data and immunological rationale for hematopoietic stem cell transplantation in autoimmunity
5. Immune cell reconstitution following autologous hematopoietic stem cell transplantation in multiple sclerosis
6. Immune reconstitution in rheumatic disease patients after autologous hematopoietic stem cell transplantation
7. The role of chemotherapy in hematopoietic stem cell transplantation HSCT for autoimmune disorders: from lymphoablative to myeloablative conditioning protocols
8. The HSCT procedure (I): mobilization, collection, manipulation and cryopreservation of HSC
9. The HSCT procedure (II): conditioning, hemopoietic stem cell infusion, supportive care and monitoring
10. Early and late complications of HSCT
11. Hematopoietic Stem Cell Transplantation for Multiple Sclerosis
12. Hematopoietic stem cell transplantation for neuromyelitis optica spectrum disorder. Can immune tolerance be re-established?
13. Hematopoietic stem cell transplantation (HSCT) for chronic inflammatory demyelinating polyradiculoneuropathy (CIDP): Is it CIDP?
14. HSCT for Stiff Person Syndrome and Myasthenia Gravis
15. Autologous hematopoietic stem cell transplantation for pediatric autoimmune neurologic disorders
16. HSCT for systemic autoimmune diseases with neurologic involvement
17. Hematopoetic Stem Cell Therapy and Ex Vivo Gene Therapy for X-linked Adrenoleukodystrophy
18. Economics of Hematopoietic Stem Cell Transplant in immune-mediated neurologic autoimmune diseases
19. The EBMT-ADWP and the CIBMTR
20. Ongoing randomized clinical trials on HSCT in multiple sclerosis