Hematopoiesis

This new volume discusses the widespread concerns of hematopoietic challenges in different and emerging ways. With chapters written by faculty and researchers from prestigious institutions working directly in hematopoiesis and advanced areas of biology, the volume offers a comprehensive overview of the regulation of blood cell development, epigenetic mechanisms, and regulatory non-coding RNAs. It presents concepts related to regulation of hematopoietic stem cell development, as well as survival, proliferation, and differentiation. It also discusses the microenvironmental niche where stem cells exist and develop into distinct blood cell types. A model system used to study non-coding RNA functions along with transformation of normal cells into cancer cell is elaborated on as well.

Key features of the book:

• Details how to utilize the available investigative tools and techniques to isolate and study single blood cells in different model systems


• Discusses the epigenetics of hematopoiesis


• Considers the clinical outcomes of defective hematopoiesis


• Describes hematopoiesis and cancer stem cells


• Looks at hematopoiesis in relation to specific diseases, such as minimal residual disease (MRD) and leukemia

This book provides valuable information related to developments in hematopoiesis that will be helpful for understanding the basics of hematopoiesis and the clinical treatment of blood diseases. Hematopoiesis: Biochemical, Cellular, Molecular, and Genomic Perspectives will be valuable to clinicians, medical school students, and researchers working in hematology.

"Provid[es] an accurate overview of the functional importance of hematopoiesis from different perspectives and the surrounding molecular mechanisms that influence the process of hematopoiesis in one way or another. Extremely pertinent and up-to-date information . . . Highly recommended . . . Sheds light on different factors that indulge and regulate the hematopoietic events. The uniqueness of this book encompasses the myriad of information on the biology of normal and aberrant hematopoiesis, epigenetic factors, and on the research tools to assist in the deeper study of aspects relating to the status of blood cells in cancerous scenario. . . . Some specifics of leukemia/lymphoma governed by various non-conventional molecules are also part of this book."

?From the Foreword by Prof. Dr. Natália Cruz-Martins, PhD, Cooperativa de Ensino Superior Politécnico e Universitário (CESPU); Faculdade de Medicina, Universidade do Porto (FMUP), Porto, Portugal