Genetic Damage in Human Spermatozoa
Series: Advances in Experimental Medicine and Biology; 1166;
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Product details:
- Edition number 2
- Publisher Springer International Publishing
- Date of Publication 24 July 2019
- Number of Volumes 1 pieces, Book
- ISBN 9783030216634
- Binding Hardback
- No. of pages210 pages
- Size 254x178 mm
- Weight 659 g
- Language English
- Illustrations XIII, 210 p. 10 illus., 9 illus. in color. Illustrations, black & white 0
Categories
Long description:
There are several types of damage that can be found in the male gamete. This book covers the genetic damage in spermatozoa that can originate during spermatogenesis, or during transit in both male and female genital tracts. Damage can also be due to ageing, environmental or iatrogenic conditions, as well as to the protocols to cryopreserve and to select spermatozoa in assisted reproduction techniques. The purpose of this book is to provide a comprehensive resource for all possible DNA damages in sperm, the relation to fertility and infertility, and possible transgenerational heritable effects.
MoreTable of Contents:
Genetic factors affecting sperm chromatin structure.- Mechanisms of origin of chromosome deletions and rearrangements in spermatozoa.- The sperm epigenome: implications for ART outcomes.- Epigenetic transgenerational inheritance.- Environmental genetic and epigenetic sperm alterations.- Sperm DNA fragmentation: mechanisms of origin.- Sperm DNA fragmentation: consequences for reproduction.- Oxidative damage to sperm DNA: attack and defence.- Interventions to prevent sperm DNA damage effects on reproduction.-Cryopreservation of sperm: effects on chromatin and strategies to prevent them.- Effect on sperm DNA quality following sperm selection for ART: new insights.- Sperm DNA damage in cancer patients.- Index.
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