Gene Genealogies, Variation and Evolution: A primer in coalescent theory
A Primer in Coalescent Theory
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Product details:
- Publisher OUP Oxford
- Date of Publication 9 December 2004
- ISBN 9780198529965
- Binding Paperback
- No. of pages296 pages
- Size 245x172x15 mm
- Weight 610 g
- Language English
- Illustrations numerous line figures 0
Categories
Short description:
Authored by leading experts, this seminal text presents a straightforward and elementary account of coalescent theory, which is a central concept in the study of genetic sequence variation observed in a population. Rich in examples and illustrations it is ideal for a graduate course in statistics, population, molecular and medical genetics, bioscience and medicine, and for students studying the evolution of human population and disease. It is also an invaluable reference for bioscientists and statisticians in the pharmaceutical industry and academia
MoreLong description:
Coalescent theory is a central concept in the study of genetic sequence variation that probabilistically describes the genealogy relating the sampled sequences. In this text, besides fulfilling the glaring need for such a book, the authors present this theory in a straightforward and elementary manner and describe the statistical and computational methods used in modelling and analyzing genetic sequence variation.
Rich in examples and illustrations the book covers basic concepts, complications arising from geographical structure and recombination before considering aspects of statistical inference based on these models. The book ends with chapters on Gene Mapping, which combines sequence variation data with phenotypic data (such as disease) to define areas of the genome where genes are responsible for the trait, and Human Evolution, a research area that is experiencing a renaissance due to the enormous amounts of data produced in molecular studies.
Authored by leading experts, this seminal text presents a straightforward and elementary account of coalescent theory, which is a central concept in the study of genetic sequence variation observed in a population. It is highly suitable for a graduate course in statistics, population, molecular and medical genetics, bioscience and medicine and students studying the evolution of human population and disease, and will be an invaluable reference for bioscientists and statisticians in the pharmaceutical industry and academia
an excellent and timely book that should appeal to a variety of people in genetics and applied mathematics.
Table of Contents:
Preface
The basic coalescent
From genealogies to sequences
Trees and topologies
Extensions to the basic coalescent
The coalescent with recombination
Getting parameters from data
LD Mapping and the coalescent
Human evolution
Appendix: Web based tools
