| ISBN13: | 9789811526039 |
| ISBN10: | 9811526036 |
| Binding: | Hardback |
| No. of pages: | 318 pages |
| Size: | 235x155 mm |
| Weight: | 670 g |
| Language: | English |
| Illustrations: | 10 Illustrations, black & white; 32 Illustrations, color |
| 221 |
Engineering of Microbial Biosynthetic Pathways
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This book provides a comprehensive overview of the basic and advanced metabolic engineering technologies used to generate natural metabolites and industrially important biomolecules.
Metabolic engineering has the potential to produce large quantities of valuable biomolecules in a renewable and sustainable manner by extending or modifying biosynthetic pathways in a wide range of organisms. It has been successfully used to produce chemicals, drugs, enzymes, amino acids, antibiotics, biofuels, and industrially important pharmaceuticals.
The book comprehensively reviews the various metabolites detection, extraction and biosensors and the metabolic engineering of microbial strains for the production of industrially useful enzymes, proteins, organic acids, vitamins and antibiotics, therapeutics, chemicals, and biofuels. It also discusses various genetic engineering and synthetic biology tools for metabolic engineering. In closing, the book discusses ethical, patenting and regulatory issues in the metabolic engineering of microbes. This book is a valuable source not only for beginners in metabolic engineering, but also students, researchers, biotechnology and metabolic engineering based company.
This book provides a comprehensive overview of the basic and advanced metabolic engineering technologies used to generate natural metabolites and industrially important biomolecules.
Metabolic engineering has the potential to produce large quantities of valuable biomolecules in a renewable and sustainable manner by extending or modifying biosynthetic pathways in a wide range of organisms. It has been successfully used to produce chemicals, drugs, enzymes, amino acids, antibiotics, biofuels, and industrially important pharmaceuticals.
The book comprehensively reviews the various metabolites detection, extraction and biosensors and the metabolic engineering of microbial strains for the production of industrially useful enzymes, proteins, organic acids, vitamins and antibiotics, therapeutics, chemicals, and biofuels. It also discusses various genetic engineering and synthetic biology tools for metabolic engineering. In closing, the book discusses ethical, patenting and regulatory issues in the metabolic engineering of microbes. This book is a valuable source not only for beginners in metabolic engineering, but also students, researchers, biotechnology and metabolic engineering based company.
Chapter 1. Fundamental Of Metabolic Engineering.- Chapter 1.1. Introduction to metabolic engineering.- Chapter 1.2. Mathematical modeling of metabolic pathways.- Chapter 1.3. Strain development and improvement.- Chapter 1.4. Microbial strain engineering.- Chapter 1.5. Techniques for detection and extraction of metabolites.- Chapter 1.6. Development of biosensor for detection of metabolites.- Chapter 2. Advanced tools for genetic engineering.- Chapter 2.1. Synthetic biology toolbox for metabolic engineering.- Chapter 2.2. CRISPR-Cas system for metabolic engineering.- Chapter 2.3. Recent advances in genetic engineering tools for metabolic engineering.- Chapter 2.3.1. Promoter engineering.- Chapter 2.3.2. Ribosome binding site engineering.- Chapter 2.3.3. Transcription factor engineering and riboregulator.- Chapter 2.3.4. Riboswitch, oscillator, biological gate, and amplifier.- Chapter 2.3.5. Cell free protein synthesis system, plasmid engineering, advanced cloning techniques, codon optimization, and recombination.- Chapter 2.3.6. Multiplex automated genome engineering, synthetic regulatory RNA, and microfluidics.- Chapter 2.4. Recent techniques for building of biosynthetic pathways.- Chapter 2.4. Ethical, patent and regulatory issues.- Chapter 3. Engineering of the natural products and biosythetic pathways.- Chapter 3.1. Amino acids.- Chapter 3.2.Vitamins.- Chapter 3.3. Organic acids.- Chapter 3.4. Polysaccharides.- Chapter 3.5. Industrial proteins and enzymes.- Chapter 3.6. Industrial proteins and enzymes.- Chapter 3.7. Therapeutics.- Chapter 3.8. Industrial chemicals.- Chapter 3.9. Biofuels.- Chapter 3.10. Flavours and fragrance.- Chapter 3.11. Isoprenoids pathway.- Chapter 3.12. Environmental pollutants.
