Day's Veterinary Immunology: Principles and Practice

Day's Veterinary Immunology

Principles and Practice
Edition number: 3
Publisher: CRC Press
Date of Publication:
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Product details:

No. of pages:432 pages
Size:254x178 mm
Weight:980 g
Illustrations: 348 Illustrations, color; 244 Halftones, color; 104 Line drawings, color; 20 Tables, color
Short description:

Updated by Brian Catchpole and Harm HogenEsch with advances in knowledge since 2014, this third edition reflects the rapid development in the field internationally, while preserving the strengths of Day's original writing.

Long description:

Michael Day's Veterinary Immunology: Principles and Practice is the adopted text in numerous veterinary schools throughout the world. Updated and revised by Brian Catchpole and Harm HogenEsch with advances in knowledge since 2014, this third edition reflects the rapid developments in the field internationally, while preserving the strengths of Day's original writing. It adds numerous case studies demonstrating the clinical context across companion and farm animals.

The textbook presents information on commonly used diagnostic test procedures and includes learning objectives at the start and key points at the end of each chapter, standard symbols in diagrams throughout the text to provide continuity, clinical examples and clinicopathological figures throughout, and a glossary of terms and list of commonly used abbreviations. Short animations are viewable via the Support Materials tab on the Routledge webpage, adding a new element of practical application.

Exploring the immunological principles of both large and small animals, the book emphasizes immunological principles while applying them to disease processes and to clinical practice. It provides a practical textbook for veterinary students and a handy reference for practitioners.

Praise for the previous editions

"Information is clearly presented and well written, layering immunological knowledge with each chapter. I found the chapter lengths perfect ? providing comprehensive information without being overwhelming. The objectives of each chapter are defined at the beginning and key points concisely reviewed at the end, allowing easy navigation and assisting comprehension. The excellent illustrations are a boon for visual learners. Immunological systems, diagnostic test procedures, clinical disease, therapy, and recent developments in the field are explored. Finally a series of case studies helps bring together and test your understanding. ... A practical textbook for students and handy reference for clinicians. ... the authors kept a challenging subject alive with analogy, illustration and clear explanations, providing a basic knowledge of immune function and clearly relating this to clinical practice. I would recommend this book to anyone challenged, intrigued or inspired by veterinary immunology."
?Caroline Blundell, BVetMed CertSAM RCVS, in the Journal of Feline Medicine and Surgery

"... an excellent tool to understand the basic principles of immunology and veterinary immunology. ... updated with the most recent advances in veterinary immunology developments. ... the basic knowledge provided is always practice-oriented, with practical examples on disease pathogenesis and diagnosis. This is why this book is not only a useful tool for undergraduates, but also for postgraduate veterinarians either doing a PhD, internship or residency in any area of veterinary medicine. But it is also a useful tool for veterinary clinicians who are keen to have a solid and deeper understanding of the immunology of diseases and routine procedures (such as vaccination or immunotherapy). ... The format of this book is very helpful, with a great number of illustrations and graphics that I found extremely valuable to gain understanding of difficult concepts or mechanisms, as well as the learning objectives and key points boxes in each chapter."
?Albert Lloret, DVM, in European Journal of Companion Animal Practice

"?an excellent companion to veterinary science students in their study of immunology and for the practising veterinarian interested in gaining a greater understanding of the principles behind clinical immunology."
?Australian Veterinary Journal

"This is a wonderful tool, very clearly designed and beautifully illustrated.. the reader is guided very logically in a journey of discovery of the immune system ?and the authors are keen on explaining clearly the latest knowledge in their field."
?Tomorrow?s Vets

"Veterinary Immunology: Principles and Practice is exactly the type of textbook necessary for teaching immunology to veterinary students. It is also an excellent reference for practitioners and residents who need to review immunology in preparation for board examinations. The format of the book is inviting, with diagrams or photographs on most pages. Tables with pertinent information are well placed and easily understood. Having taught immunology to veterinary students at the University of California -Davis for over 30 years, I appreciate the logical order in which the material is presented. ... a concise, well-written, and well-illustrated book that will be very useful for teaching veterinary immunology."
?Laurel J. Gershwin, DVM, PhD, DACVM, University of California-Davis, in Vet Med Today: Book Reviews, JAVMA

Table of Contents:

An overview of the immune system Important concepts and principles of innate and adaptive immunity. Introduction. History of immunology. The immune system: An overview. Principles of innate immunity. Principles of adaptive immunity. Evolution of the immune system. Key points. Cells and tissues of the immune system. Introduction. Haematopoesis and production of white blood cells. Primary lymphoid tissues. Secondary lymphoid tissues. The lymphatic system, lymphocyte recirculation and immune surveillance. Key points. Innate immunity. Introduction. Defensive barriers. Pattern
-recognition receptors. Phagocytes and phagocytosis. Innate lymphoid cells and natural killer cells. Lymphocytes with restricted diversity of antigen receptors. The interferon response. The inflammatory response. The acute phase response. Systemic inflammatory response syndrome. The complement system. Key points. Lymphocyte development. Introduction. Antigen recognition by lymphocytes. Development of B lymphocytes. T cell development and maturation. Key points. The major histocompatibility complex and antigen presentation. Introduction. The major histocompatibility complex. MHC class I processing pathway. MHC class II processing pathway. Antigen presentation by CD1 molecules to NKT cells. Antigen presenting cells. Genetics and inheritance of the MHC. MHC associations with immune function and disease. MHC and transplantation / tissue graft rejection. Key points. Cytokines, chemokines and their receptors. Introduction. Chemokines and chemokine receptors. Cytokines and cytokine receptors. Key points. The biology of T lymphocytes. Introduction. Chemokines and chemokine receptors. Cytokines and cytokine receptors. Key points. Antibody structure and function. Introduction. Antibody structure. Antibody binding to antigen. Biological properties of antibody. Immunoglobulin classes. Key points. The biology of B lymphocytes. Introduction. Antigen recognition by B cells. Activation of B lymphocytes. The immunoglobulin class switch. Kinetics of the antibody response. Monoclonal antibodies. Key points. Immunodiagnostics: Serology, immunoassays and measurement of cell
-mediated immunity.
Introduction. Serological tests and immunoassays. Immunophenotyping. Lymphocyte stimulation assays. Tests of cytotoxic function. Tests of phagocytic cell function. Key points. The immune response to infectious agents. Introduction. The immune response to viral infection. The immune response to bacterial infection. The immune response to helmith infection. The immune response to protozoal infection. The immune response to fungal infection. Key points. Immune evasion by pathogens. Introduction. Evading the innate immune response. Evading the antibody
-mediated adaptive immune response. Evading the cell
-mediated adaptive immune response.Specific viral strategies for immune evasion. Key points. Vaccination. Introduction. Passive immunization. Active immunization. Vaccine technologies. Vaccines for non
-infectious diseases. Vaccine adjuvants. Routes of administering vaccines. Basic principles of vaccination. Vaccination failure. Adverse consequences of vaccination. Key points. Immune system ontogeny and neonatal immunology. Introduction. Immune system ontogeny. Passive transfer of maternal immune protection. Neonatal vaccination. Failure of passive transfer. Neonatal isoerythrolysis. Early life immune development. Key points. Immunological tolerance and immune suppression. Introduction. Tolerance and tolerance mechanisms. Central tolerance. Peripheral tolerance. Mucosal tolerance. Fetomaternal and neonatal tolerance. Antibody
-mediated suppression. The neuroendocrine
-immunological loop. Key points. Immunodeficiency. Introduction. Primary immunodeficiency. Secondary immunodeficiency. Key points. Hypersensitivity reactions. Introduction. The Gell and Coombs classification of hypersensitivity. Type I hypersensitivity. Type II hypersensitivity. Type III hypersensitivity. Type IV hypersensitivity. Key points. Hypersensitivity disorders and allergic disease. Introduction. Factors predisposing to allergic disease. Systemic allergic reactions. Allergic skin disease. Respiratory disease. Gastrointestinal disease. Diagnosis of allergic disease. Key points. Autoimmunity and autoimmune disease. Introduction. The genetic basis for autoimmunity. Intrinsic / host factors in susceptibility to autoimmune disease. Extrinsic / environmental factors in susceptibility to autoimmunity. Autoimmune diseases mediated by autoantibodies. Autoimmune diseases mediated by autoreactive T cells. Diagnostic tests for autoimmune disease. Key points. Cancer immunology and immune system neoplasia. Introduction. Tumour antigens. The anti
-tumour immune response. Tumour
-promoting immune activity. Immune evasion by tumours. Immunotherapy to enhance the anti
-tumour immune response. Tumours of the immune system. Key points. Immunotherapy. Introduction. Immunosuppressive agents. Janus kinase inhibitors. Intravenous immunoglobulin therapy. Allergen
-specific immunotherapy. Monoclonal antibody therapy. Cytokine therapy. Immunostimulatory agents. Key points. Case studies in clinical immunology.