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Product details:
- Publisher Oxford University Press
- Date of Publication 19 October 2000
- Number of Volumes laminated boards
- ISBN 9780199637577
- Binding Hardback
- No. of pages508 pages
- Size 253x194x33 mm
- Weight 1309 g
- Language English
- Illustrations 4 pp colour plates, numerous line figures 0
Categories
Short description:
Combinatorial chemistry is the synthesizing and testing of arrays of compounds. The high throughput means that combinatorial techniques are increasingly used in the biomedical sciences, especially drug discovery and related pharmaceutical research. This volume is the first practical guide to combinatorial chemistry that will enable novices to carry out successful experiments.
MoreLong description:
Combinatorial Chemistry is a genuine practical guide covering all the major areas of combinatorial chemistry from an experimental and conceptual point of view. Being one of the most powerful of modern technologies, combinatorial chemistry has had implications to many areas of chemistry and biology and the current approaches to drug, catalyst, receptor, and materials development and discovery are all included in this volume. It also contains protocols on
solid, liquid, and solution phase synthesis and expedient methods of library screening and evaluation. The use of automation and robotics is also explained. It is written at a level easily accessible to novices and will enable readers to use combinatorial techniques to the best advantage.
Table of Contents:
Synthesis of combinatorial libraries using the portioning-mixing procedure
One-bead-one-compound combinatorial library method
Synthesis and screening of positional scanning synthetic combinatorial libraries
High throughput combinatorial synthesis of discrete compounds in multimilligram quantities
Positionally addressable parallel synthesis on membrane supports
Resins and anchors for solid phase organic synthesis
Organic reactions on solid support - an overview
Analytical methods in combinatorial chemistry
Multi-component reactions (mcrs) of isocyanides and their chemical libraries
Multi-step solution phase combinatorial synthesis
Experimental techniques in fluorous synthesis
Dendrimer-supported combinatorial chemistry
Automated solution phase synthesis and its application in combinatorial chemistry
Combinatorial discovery and optimization of electrocatalysts
Combinatorial library synthesis using polymer-supported catalysts
Combinatorial Approaches to chiral catalysts discovery
