Charney and Nestler's Neurobiology of Mental Illness
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Product details:
- Edition number 6
- Publisher OUP USA
- Date of Publication 23 April 2025
- ISBN 9780197640654
- Binding Hardback
- No. of pages1096 pages
- Size 282x223x52 mm
- Weight 3307 g
- Language English 725
Categories
Short description:
Charney and Nestler's Neurobiology of Mental Illness, Sixth Edition provides a concise and compelling overview of everything that is known today about all major forms of mental illness and the experimental tools that scientists, psychiatrists, and other clinicians use to advance our understanding still further. The chapters are written in layered ways to be accessible to beginners-early medical or graduate students-yet still revealing and insightful for today's experts alike. Each chapter begins with a summary and a list of key concepts that helpfully orient the reader and reinforce the most important take away messages. Didactic figures further enhance the clarity of the information conveyed.
MoreLong description:
The Sixth Edition of Charney and Nestler's Neurobiology of Mental Illness builds on previous editions of the book and reflects the continuing progress in reintegrating psychiatry into the mainstream of modern biomedical science. This reintegration remains a work in progress, based on the unique complexity of the brain and its diseases. Yet, the research tools that are transforming other branches of medicine-epidemiology, genetics, epigenetics, molecular and cell biology, imaging, and medicinal chemistry, along with fundamental advances in the neurosciences that make it possible to decipher cell types and their larger circuits to an unprecedented degree, are now at long last transforming psychiatry.
Collectively, the 75 chapters in this newly renovated textbook describe the developments in genetics and in molecular, cellular, and systems neuroscience that are breaking new ground in the diagnosis, treatment, and prevention of disabling psychiatric disorders.
In this updated edition, Section 1 focuses on the major methodological approaches to studying the biological basis of mental illness. Sections 2 through 8 each focus on a major class of mental illness, including schizophrenia, bipolar disorder, depression, anxiety and trauma disorders, substance use disorders, neurodegenerative disorders, and childhood psychiatry disorders.
The final section is a collection of essays that address what can be expected over the next decade in terms of improving psychiatric diagnosis, achieving a true precision approach to treating mental illness, along with new avenues of medication and non-medication therapies in the offing.
Table of Contents:
SECTION 1: EMERGING AND ESTABLISHED TECHNOLOGIES
Section Editors: Eric J. Nestler and Kafui Dzirasa
1. Genetic Methodologies and Applications
Ben Neale
2. Multiscale Network Approaches to Decode the Complexity
of Common Human Diseases
Minghui Wang, Yiyuan Liu, Eric Schadt, and Bin Zhang
3. The Role of the Epigenome in Brain Development, Function, and Disease
Schahram Akbarian, John F. Fullard, Kiran Girdhar, and Panos Roussos
4. Methods for In Vivo Gene Manipulation
Lisa M. Monteggia and Wei Xu
5. Application of Stem Cells to Understanding
Psychiatric Disorders
Marcella, Burtele, Giorgia Quadrato, and Kristen Brennand
6. Optogenetics and Related Technologies for Psychiatric Disease Research: Current Status and Challenges
Lief E. Fenno and Karl Deisseroth
7. Methods for In Vivo Circuit Analysis
Micah Johnson, Yassine Filali, Radha Velamuri, Kafui Dzirasa, and Rainbo Hultman
8. Magnetic Resonance Methodologies
Hanzhang Lu and Peter A. Bandettini
9. PET Brain Imaging Methodologies
Ansel Hillmer, Kelly P. Cosgrove, and Richard E. Carson
10. Neuromodulation and Psychiatric Disorders
Andrew Smith, Martijn Figee, and Helen Mayberg
SECTION 2: SCHIZOPHRENIA
Section Editors: Judy Ford and Dan Mathalon
11. Diagnosis and Epidemiology of Schizophrenia
Julie Walsh-Messinger, Ariella Farzan Nikou, and Dolores Malaspina
12. Genetics of Schizophrenia
Sophie E. Legge, Antonio F. Pardi?as, and Michael C. O'Donovan
13. Neuroimaging and Circuit Mechanisms of Schizophrenia
Neil D. Woodward, Stephan Heckers, Dost Ongur, and Julia M. Sheffield
14. Animal and Cellular Models for the Study of Schizophrenia
Joshua A. Gordon
15. Neural and Circuit Mechanisms of Schizophrenia
Samuel J. Dienel and David A. Lewis
16. Glial-Immune Mechanisms of Schizophrenia: Animal and Human Studies
Kowsar Teymouri, Mahbod Ebrahimi, Jennie G. Pouget, and James L. Kennedy
17. Translational Models for Psychotic Symptoms
Phil Corlett
18. Current Treatments for Schizophrenia
Donald C. Goff
19. Novel Approaches for Treating Schizophrenia
Steve M. Paul and Alan Breier
SECTION 3: BIPOLAR DISORDER
Section Editor: Alex Charney
20. Diagnosis and Epidemiology of Bipolar Disorder
Kathleen R. Merikangas and Emma K. Stapp
21. Genetics of Bipolar Disorder
Dongjing Liu and Niamh Mullins
22. Neuroimaging and Circuit Mechanisms of Bipolar Disorder
E. Kale Edmiston, Michele A. Bertocci, Merage Ghane-Ezabadi, and Mary L. Phillips
23. Animal and Cellular Models for the Study of Bipolar Disorder
Michael J. McCarthy and Jared W. Young
24. Molecular and Cellular Mechanisms of Bipolar Disorder: Animal and Human Studies
Colleen A. McClung and Hilary P. Blumberg
25. Current Treatments for Bipolar Disorder
Nicole W. Simons and Alexander W. Charney
26. Novel Approaches for Treating Bipolar Disorder
Nefize Yalin, Allan H. Young, and Carlos A. Zarate, Jr.
SECTION 4: DEPRESSION
Section Editor: John Krystal
27. Diagnosis and Epidemiology of Depression
James W. Murrough
28. Genetics of Depression
Daniel Levey and Joel Gelernter
29. Neuroimaging and Circuit Mechanisms of Depression
Adrienne L. Romer, Michele A. Bertocci, Mary L. Phillips, and Diego A. Pizzagalli
30. Animal Models for the Study of Depression
Lyonna F. Parise, Astrid M. Cardona-Acosta, Eric M. Parise, and Carlos A. Bola?os-Guzm
