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  • Quinones and Quinone Enzymes, Part B

    Quinones and Quinone Enzymes, Part B by Sies, Helmut; Packer, Lester;

    Series: Methods in Enzymology; 382;

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      • Publisher's listprice EUR 170.00
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    Product details:

    • Publisher Academic Press
    • Date of Publication 8 March 2004

    • ISBN 9780121827861
    • Binding Hardback
    • No. of pages572 pages
    • Size 228x152 mm
    • Weight 960 g
    • Language English
    • Illustrations Approx. 150 illustrations
    • 0

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    Long description:

    Quinones are members of a class of aromatic compounds with two oxygen atoms bonded to the ring as carbonyl groups. This volume covers more clinical aspects of quinines, such as anticancer properties, as well as their role in nutrition and in age-related diseases.

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    Table of Contents:

    Section I: Mitochondrial Ubiquinone and Reductases

    1: Mitochondrial Quinone Reductases: Complex I

    2: Q-Cycle Bypass Reactions at the Qo Site of the Cytochrome bc1 (and Related) Complexes

    3: Targeting Coenzyme Q Derivatives to Mitochondria

    4: The Mitochondrial Interplay of Ubiquinol and Nitric Oxide in Endotoxemia

    5: Mitochondrial Respiratory Chain Dysfunction Caused by Coenzyme Q Deficiency

    6: Coenzyme Q Cytoprotective Mechanisms

    7: Dietary Coenzyme Q10 and Mitochondrial Status

    Section II: Anticancer Quinones and Quinone Oxidoreductases

    8: NAD(P)H:Quinone Oxidoreductase 1 (NQO1, DT-Diaphorase), Functions and Pharmacogenetics

    9: Structure and Mechanism of NAD[P]H:Quinone Acceptor Oxidoreductases (NQO)

    10: Diaziridinylbenzoquinones

    11: Quinone Reductase-Mediated Nitro-Reduction: Clinical Applications

    12: Bioactivation and Resistance to Mitomycin C

    13: NAD(P)H:Quinone Oxidoreductase 1 Expression, Hydrogen Peroxide Levels, and Growth Phase in HeLa Cells

    14: The "Prochaska” Microtiter Plate Bioassay for Inducers of NQO1

    15: Structure-Activity Relationships in Two-Electron Reduction of Quinones

    16: p53-Dependent Apoptosis and NAD(P)H:Quinone Oxidoreductase 1

    17: The Role of Endogenous Catechol Quinones in the Initiation of Cancer and Neurodegenerative Diseases

    18: Induction of NQO1 in Cancer Cells

    Section III: Quinone Reductases: Chemoprevention and Nutrition

    19: Role of Nicotinamide Quinone Oxidoreductase 1 (NQO1) in Protection against Toxicity of Electrophiles and Reactive Oxygen Intermediates

    20: Activation and Detoxification of Naphthoquinones by NAD(P)H: Quinone Oxidoreductase

    21: Induction of Quinone Reductase as a Primary Screen for Natural Product Anticarcinogens

    22: Chemoprevention by 1,2-Dithiole-3-Thiones Through Induction of NQO1 and Other Phase 2 Enzymes

    23: Chemical Structures of Inducers of Nicotinamide Quinone Oxidoreductase 1 (NQO1)

    24: Induction of Phase II Enzymes by Aliphatic Sulfides Derived from Garlic and Onions: An Overview

    25: Upregulation of Quinone Reductase by Glucosinolate Hydrolysis Products From Dietary Broccoli

    Section IV: Quinones and Age-Related Diseases

    26: Therapeutic Effects of Coenzyme Q10 in Neurodegenerative Diseases

    27: Neuroprotective Actions of Coenzyme Q10 in Parkinson's Disease

    Author Index

    Subject Index

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