Long description:

In this issue of Clinics in Liver Disease, guest editor Dr. John V. Binu brings his considerable expertise to the topic of Primary Biliary Cholangitis. PBC leads to inflammation and scarring of the small bile ducts, and, if untreated, can lead to cirrhosis and liver failure. In this issue, top experts provide a state-of-the-art review of diagnosis and treatment for this chronic, progressive liver disorder.

• Contains 13 practice-oriented topics including genetics of primary biliary cholangitis; prognostic scoring systems in PBC; overlap syndromes and PBC; non-invasive evaluation of fibrosis and portal hypertension in PBC; treatment of PBC: first- and second-line therapies; novel therapies for PBC; and more. 

• Provides in-depth clinical reviews on primary biliary cholangitis, offering actionable insights for clinical practice. 

• Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews. 

Table of Contents:

Contemporary Epidemiology of Primary Biliary Cholangitis
Genetics of Primary Biliary Cholangitis
Immunologic Responses and the Pathophysiology of Primary Biliary Cholangitis
Autoantibodies in Primary Biliary Cholangitis
Prognostic Scoring Systems in Primary Biliary Cholangitis: An Update
Primary Biliary Cholangitis in Males: Pathogenesis, Clinical Presentation, and Prognosis
The Inconvenient Truth of Primary Biliary Cholangitis/Autoimmune Hepatitis Overlap Syndrome
Noninvasive Evaluation of Fibrosis and Portal Hypertension in Primary Biliary Cholangitis
Hepatocellular Carcinoma in Primary Biliary Cholangitis
Treatment of Primary Biliary Cholangitis: First-Line and Second-Line Therapies
Evaluation and Management of Pruritus in Primary Biliary Cholangitis
Novel Therapies in Primary Biliary Cholangitis: What Is in the Pipeline?
Liver Transplantation for Primary Biliary Cholangitis