Short description:

Ischemic brain damage represents a major source of morbidity and mortality in westernized society and poses a significant financial burden on the health care system. To date, few effective therapies have been realized to treat stroke and promising avenues have not proven clinically useful. Recent evidence, however, suggests that channels, pumps, and ionic exchangers are involved in CNS ischemia and ischemic stroke, but the potential contribution of these channels for curing stroke is far less understood than for many other normal and pathological conditions. New Strategies in Stroke Intervention: Ionic Channels, Pumps, and Transporters analyzes the roles played by targets in stroke development and the potential action of drugs modulating these proteins. This book provides a groundbreaking review of these ionic channels, pumps, and transporters as regulators of neuronal ionic homeostasis, providing a better understanding of ischemic brain disorders and the new pharmacological avenues for a cure. It will be a useful tool for researchers working in this field, and any student interested in the physiological, pathophysiological, and pharmacological features of stroke damage. 

About the Editor:

Lucio Annunziato is a professor of pharmacology in the School of Medicine at the University of Naples ??Federico II??, Italy. He is coordinator of the University's neuroscience Ph.D. program and director of the Department of Neuroscience. He is also the president elect of the Italian Society of Neuroscience. Dr. Annunziato has authored more than 150 full papers and his scientific interest is mainly devoted to the molecular pharmacology of plasma membrane transporters and ionic channels involved in the pathophysiology of stroke. Most of his recent papershave appeared in the most qualified international journals in the field of ischemic neurodegeneration.

Long description:

Ischemic brain damage represents a major source of morbidity and mortality in westernized society and poses a significant financial burden on the health care system. To date, few effective therapies have been realized. Recent evidence, however, suggests that channels, pumps, and ionic exchangers are involved in CNS ischemia and ischemic stroke, but the potential contribution of these channels for curing stroke is far less understood than for many other normal and pathological conditions. New Strategies in Stroke Intervention: Ionic Channels, Pumps, and Transporters, analyzes the roles played by targets in stroke development and the potential action of drugs modulating these proteins. This book provides a groundbreaking review of these ionic channels, pumps, and transporters as regulators of neuronal ionic homeostasis, providing a better understanding of ischemic brain disorders and the new pharmacological avenues for a cure.

From the reviews:

?This book on ionic channels in cerebral ischemia is a very detailed analysis of the recent literature on the subject with a wide and in depth scope. The book is meant for the seasoned and trained brain ischemia researcher as well as neurologists with an avid interest in this area. ? this book is going to serve a wide purpose as a reference book and a read as you go book for physiologists, neuroscientists, neurologists, and neurosurgeons.? (Joseph J. Grenier, Amazon.com, September, 2013)

??New Strategies in Stroke Intervention? provides a succinct review of several novel concepts which might prove to be of ultimate clinical relevance in stroke management. ? Each chapter provides an index typically listing 50-150 references. The information provided will be understandable to clinicians who might not have extensive genetic, molecular or biophysiological or pharmacological backgrounds. ? will be of particular interest to Stroke clinicians and Fellows and to other Neuroscientists engaged in brain ischemia research.? (Christopher Voll, Le Journal Canadien Des Sciences Neurologiques, Vol. 37 (6), November, 2010)

?New Strategies in Stroke Intervention provides an in-depth summary of the present understanding of most of the major ion channels, pumps, and transporters, implicated in ischaemic neuronal death ? . it will provide an important reference on the pathophysiology of stroke for those with an interest in stroke medicine. This book succinctly summarises a large amount of published work and will provide a useful grounding for readers, as new discoveries are made.? (Neil Spratt, The Lancet Neurology, Vol. 9, July, 2010)

Table of Contents:

Basis of Ionic Dysregulation in Cerebral Ischemia.- Why have Ionotropic and Metabotropic Glutamate Antagonists Failed in Stroke Therapy?.- Mitochondrial Channels as Potential Targets for Pharmacological Strategies in Brain Ischemia.- Endoplasmic Reticulum Calcium Homeostasis and Neuronal Pathophysiology of Stroke.- The Na + /Ca 2+ Exchanger: A Target for Therapeutic Intervention in Cerebral Ischemia.- The ?Loop? Diuretic Drug Bumetanide-Sensitive Na + -K + -Cl - Cotransporter in Cerebral Ischemia.- The Na + /H + Exchanger: A Target for Therapeutic Intervention in Cerebral Ischemia.- The Na + /K + -ATPase as a Drug Target for Ischemic Stroke.- Acid-Sensing Ion Channels (ASICs): New Targets in Stroke Treatment.- Role of TRPM7 in Ischemic CNS Injury.- Subtypes of Voltage-Gated Ca 2+ Channels and Ischemic Brain Injury.- The Diverse Roles of K + Channels in Brain Ischemia.- Clinical Trials with Drugs Targeting Ionic Channels, Antiporters, and Pumps in Ischemic Stroke.