MHC Class-I Loss and Cancer Immune Escape
Series: Advances in Experimental Medicine and Biology; 1151;
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Product details:
- Edition number 1st ed. 2019
- Publisher Springer
- Date of Publication 12 June 2019
- Number of Volumes 1 pieces, Book
- ISBN 9783030178635
- Binding Hardback
- No. of pages101 pages
- Size 254x178 mm
- Weight 540 g
- Language English
- Illustrations 3 Illustrations, black & white; 38 Illustrations, color 11
Categories
Short description:
This book is about the escape strategies used by cancer cells to avoid the immune response of the host. The main characters of this story are the ?Antigen Presenting Molecules? and the ?T Lymphocytes?. The former are known as the Major Histocompatibility Complex (MHC): the H-2 and the HLA molecules. The latter are a subgroup of white cells travelling all over our body which are capable to distinguish between ?self and non self?.
Readers will know from the inside about the history of the HLA genetic system and will discover how T lymphocytes recognize and destroy cancer cells. One of the key important questions is: Why tumors arise, develop and metastasize? This book tries to answer this question and will explain how cancer cells become invisible to killer T lymphocytes. The loss of the HLA molecules is a major player in this tumor escape mechanism.
Cancer immunotherapy is aimed at stimulating T lymphocytes to destroy tumor cells. However, the clinical response rate is not as high as expected. The molecular mechanisms responsible for MHC/HLA antigen loss play a crucial role in this resistance to immunotherapy. This immune escape mechanism will be discussed in different types of tumors: lung, prostate, bladder and breast?ect. as well as melanoma and lymphoma.
This book will be useful to Oncologists, Pathologists and Immunologist that will enter this fascinating area of research. It will be also interesting for biologist, doctoral students and medical residents interested in ?Tumor Immunology?.
MoreLong description:
This book is about the escape strategies used by cancer cells to avoid the immune response of the host. The main characters of this story are the ?Antigen Presenting Molecules? and the ?T Lymphocytes?. The former are known as the Major Histocompatibility Complex (MHC): the H-2 and the HLA molecules. The latter are a subgroup of white cells travelling all over our body which are capable to distinguish between ?self and non self?.
Readers will know from the inside about the history of the HLA genetic system and will discover how T lymphocytes recognize and destroy cancer cells. One of the key important questions is: Why tumors arise, develop and metastasize? This book tries to answer this question and will explain how cancer cells become invisible to killer T lymphocytes. The loss of the HLA molecules is a major player in this tumor escape mechanism.
Cancer immunotherapy is aimed at stimulating T lymphocytes to destroy tumor cells. However, the clinical response rate is not as high as expected. The molecular mechanisms responsible for MHC/HLA antigen loss play a crucial role in this resistance to immunotherapy. This immune escape mechanism will be discussed in different types of tumors: lung, prostate, bladder and breast?ect. as well as melanoma and lymphoma.
This book will be useful to Oncologists, Pathologists and Immunologist that will enter this fascinating area of research. It will be also interesting for biologist, doctoral students and medical residents interested in ?Tumor Immunology?.
More
Table of Contents:
Preface.- Introduction.- Mhc/Hla Class I Loss In Cancer Cells.- Hla Class-I Expression And Cancer Immunotherapy.- Hla Class-Ii Expression In Human Tumors.- Index.
MHC Class-I Loss and Cancer Immune Escape
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