Gene Therapy in Neurological Disorders
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Product details:
- Publisher Elsevier Science
- Date of Publication 30 May 2018
- ISBN 9780128098134
- Binding Hardback
- No. of pages450 pages
- Size 234x190 mm
- Weight 1180 g
- Language English 0
Categories
Long description:
Gene therapy has tremendous potential for the treatment of neurological disorders. There has been substantial progress in the development of gene therapy strategies for neurological disorders over the last two decades. Gene Therapy in Neurological Disorders thoroughly reviews currently available gene therapy tools and presents examples of their application in a variety of neurological diseases. The book begins with general reviews of gene therapy strategies with a focus on neurological disorders. The remainder of the chapters present approaches to specific neurological disorders. Each chapter gives an in-depth introduction to the relevant field before diving into the specific tool or application. The book aims to help investigators, students and research staff better understand the principles of gene therapy and its application in the nervous system.
MoreTable of Contents:
Section Iï¿1⁄2 Overview and Methods
1. Gene therapy methods and their applications in neurological disorders
2. Targeting transgene and RNA interference-based gene silencing sequences to astrocytes using viral vector-mediated approaches
3. Gene therapy using genomic DNA: Advances and challenges
4. Stem cell-based gene therapy in neurological disorders
Section IIï¿1⁄2 Approaches to specific disorders
5. Targeting astrocytes with viral gene therapy for Alzheimer's disease
6. Prophylactic and therapeutic applications of catalytic immunoglobulin gene delivery in a mouse model of Alzheimer's disease
7. Lentiviral vector delivery of orexin gene to study potential role of orexin and sleep modulation in the pathogenesis of Alzheimer's disease
8. Pharmacologically controlled neurotrophic factor gene therapy for Parkinsonï¿1⁄2s Disease
9. Gene therapy as a novel target for treatment of symptoms and medication complications in Parkinson's disease
10. Inhibition of aggregation of mutant huntingtin by nucleic acid aptamers in vitro and in a yeast model of Huntington's disease
11. Intraspinal delivery of recombinant AAV mediated Interleukin-10 modifies disease in ALS mice.
12. Differentiation of human induced pluripotent stem cells to Purkinje neurons
13. Expressing full-length dystrophin using adeno-associated virus
14. Genome editing therapy for Duchenne muscular dystrophy
15. AAV vector mediated gene delivery to neurons and glial cells in damaged spinal cord
16. Transplantation of human induced pluripotent stem cell-derived neural precursor cells for treatment of spinal cord injury
17. Viral transduction of primary Schwann cells using a Cre-lox system to regulate GDNF expression
18. Application of Herpes simplex virus vectors in treatment of neuropathic pain
19. Oncolytic virotherapy for gliomas: a preclinical and clinical summary
