Drug Resistance in Cancer
Mechanisms and Models
- Publisher's listprice GBP 148.00
-
74 902 Ft (71 336 Ft + 5% VAT)
The price is estimated because at the time of ordering we do not know what conversion rates will apply to HUF / product currency when the book arrives. In case HUF is weaker, the price increases slightly, in case HUF is stronger, the price goes lower slightly.
- Discount 20% (cc. 14 980 Ft off)
- Discounted price 59 922 Ft (57 069 Ft + 5% VAT)
Subcribe now and take benefit of a favourable price.
Subscribe
74 902 Ft
Availability
Estimated delivery time: In stock at the publisher, but not at Prospero's office. Delivery time approx. 3-5 weeks.
Not in stock at Prospero.
Why don't you give exact delivery time?
Delivery time is estimated on our previous experiences. We give estimations only, because we order from outside Hungary, and the delivery time mainly depends on how quickly the publisher supplies the book. Faster or slower deliveries both happen, but we do our best to supply as quickly as possible.
Product details:
- Publisher Cambridge University Press
- Date of Publication 8 October 1998
- ISBN 9780521482738
- Binding Hardback
- No. of pages256 pages
- Size 236x158x21 mm
- Weight 530 g
- Language English
- Illustrations 22 b/w illus. 6 tables 0
Categories
Short description:
An accessible and sophisticated account of the biological mechanisms of drug resistance in cancer and their mathematical modelling.
MoreLong description:
Drug resistance in cancer, whereby a proportion of cancer cells evades chemotherapy, poses a profound and continuing challenge for the effective treatment of cancer. The principles underlying the biological mechanisms behind this phenomenon are clearly understood and explained in this volume. However, a deeper understanding of drug resistance requires a quantitative appreciation of the dynamic forces that shape tumour growth, including spontaneous mutation and selection processes. The authors seek to explain and to simplify these complex mechanisms, and to place them in a clinical context. Clearly explained mathematical models are used to illustrate the biological principles and provide an insight into tumour development and the effectiveness and limitations of drug treatment. It is suitable for those with a non-mathematical background and aims to enhance the effectiveness of cancer therapy.
'However, this volume provides a very good overview of the drug resistance field with special emphasis on mathematical models and can be recommended to everyone interested in the field. Even those who see math as an alien subject will find this book useful, since the mathematical portions of the text have been kept as straightforward as possible. The book is a good source of references and suggestions for further reading and should interest a wide readership including clinicians, molecular biologists, and researchers interested in tumor growth, tumor killing and mutation models.' V. Spataro, Annals of Oncology
Table of Contents:
Preface; 1. The biological basis of cancer and the problem of drug resistance; 2. Tumour growth, stem cells and experimental chemotherapy; 3. Molecular aspects of drug resistance; 4. Quantitative descriptions of the origins of drug resistance; 5. Development and exploration of the random mutation model for drug resistance; 6. Extensions of the random mutation model for drug resistance; 7. Clinical predictions of the random mutation model; 8. Directed versus random mutation and the problem of intrinsic resistance; 9. Some final thoughts on the problem of drug resistance; Index.
More
