Biochemistry and Physiology of the Neutrophil
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Estimated delivery time: In stock at the publisher, but not at Prospero's office. Delivery time approx. 3-5 weeks.
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Product details:
- Edition number Paperback Version
- Publisher Cambridge University Press
- Date of Publication 25 March 1994
- ISBN 9780521416986
- Binding Hardback
- No. of pages320 pages
- Size 237x158x22 mm
- Weight 591 g
- Language English
- Illustrations 97 b/w illus. 7 tables 0
Categories
Short description:
This book provides an up-to-date review of the role of the neutrophil in infection and inflammation.
MoreLong description:
This book describes the role of the neutrophil in infection and inflammation and provides an up-to-date review of the biochemistry and physiology of these cells, highlighting the mechanisms by which they seek out and destroy pathogenic micro-organisms. The development of these cells during haematopoiesis is described and the mechanisms which lead to the production of reactive oxidants and the intracellular signal transduction systems which lead to the cell's activation are reviewed. The book also discusses recent discoveries concerning the role of cytokines in the regulation of neutrophil function together with the importance of the neutrophil as a generator of inflammatory cytokines. Finally there is a description of the biochemical defects that give rise to some of the neutrophil-associated human diseases.
"...a useful basic reference and I would recommend it to immunologists, microbiologists, biochemists, physiologists, infectious disease specialists, hematologists, or to anyone whose interest lies in immunology or microbiology." John O. Naim, Immunological Investigations
Table of Contents:
1. Neutrophils and host defence: the fight against infection; 2. The development and structure of neutrophils; 3. The generation and recognition of neutrophil-activating factors: structure and function of neutrophil receptors; 4. The cytoskeleton: the molecular framework regulating cell shape and the traffic of intracellular components; 5. The respiratory burst: the generation of reactive oxygen metabolites and their role in microbial killing; 6. Neutrophil activation: the production of intracellular signalling molecules; 7. Neutrophil priming: regulation of neutrophil function during inflammatory activation; 8. Disorders of neutrophil function; Index.
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