The Optical Clearing Method by Oliveira, Luís Manuel Couto; Tuchin, Valery Victorovich;

A New Tool for Clinical Practice and Biomedical Engineering

Sorozatcím: SpringerBriefs in Physics;

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A termék adatai:

Kiadás sorszáma 1st ed. 2019
Kiadó Springer International Publishing
Megjelenés dátuma 2019. december 6.
Kötetek száma 1 pieces, Book

ISBN 9783030330545
Kötéstípus Puhakötés
Terjedelem177 oldal
Méret 235x155 mm
Súly 454 g
Nyelv angol
Illusztrációk XI, 177 p. 53 illus., 47 illus. in color. Illustrations, black & white

Kategóriák

Biotechnológia Biokémia Biofizika Orvosi biotechnológia Biotechnológia (karitatív célú kampány) Biokémia (karitatív célú kampány) Biofizika (karitatív célú kampány) Orvosi biotechnológia (karitatív célú kampány)

Hosszú leírás:

This book describes the Optical Immersion Clearing method and its application to acquire information with importance for clinical practice and various fields of biomedical engineering. The method has proved to be a reliable means of increasing tissue transparency, allowing the investigator or surgeon to reach deeper tissue layers for improved imaging and laser surgery. This result is obtained by partial replacement of tissue water with an active optical clearing agent (OCA) that has a higher refractive index and is a better match for the refractive index of other tissue components. Natural tissue scattering is thereby reduced. An exponential increase in research using this method has occurred in recent years, and new applications have emerged, both in clinical practice and in some areas of biomedical engineering. Recent research has revealed that treating ex vivo tissues with solutions containing active OCAs in different concentrations produces experimental data to characterize drug delivery or to discriminate between normal and pathological tissues. The obtained drug diffusion properties are of interest for the pharmaceutical and organ preservation industry. Similar data can be estimated with particular interest for food preservation. The free water content evaluation is also of great interest since it facilitates the characterization of tissues to discriminate pathologies. An interesting new application that is presented in the book regards the creation of two optical windows in the ultraviolet spectral range through the application of the immersion method. These induced transparency windows open the possibility to diagnose and treat pathologies with ultraviolet light. This book presents photographs from the tissues we have studied and figures that represent the experimental setups used. Graphs and tables are also included to show the numerical results obtained in the sequential calculations performed.

Több

Tartalomjegyzék:

Chapter1. Tissue Optics.- Chapter2. Controlling the optical properties of biological materials.- Chapter3. Typical optical clearing agents.- Chapter4. Major optical clearing mechanisms.- Chapter5. Measurements during optical clearing.- Chapter6. Data that can be acquired from optical clearing studies.- Chapter7. Optical clearing and tissue imaging.- Chapter8. Other applications of OCAs.- Chapter9. Future perspectives of the optical clearing method.

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