Mechanisms of Gene Regulation: How Science Works
Kiadás sorszáma: 1st ed. 2020
Kiadó: Springer
Megjelenés dátuma: 2020. október 30.
Kötetek száma: 1 pieces, Book
Normál ár:
Kiadói listaár:
EUR 77.99
Prospero ár:
EUR 76.99
Prospero ár érvényessége:
2024. március 31.
EUR 76.99
Prospero ár érvényessége:
2024. március 31.
Becsült forint ár:
30 650 helyett
31 769 Ft (30 257 Ft + 5% áfa) , megtakarítás: kb. 393 Ft + 5% áfa
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31 769 Ft (30 257 Ft + 5% áfa) , megtakarítás: kb. 393 Ft + 5% áfa
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A termék adatai:
ISBN13: | 9783030523206 |
ISBN10: | 3030523209 |
Kötéstípus: | Puhakötés |
Terjedelem: | 149 oldal |
Méret: | 235x155 mm |
Súly: | 454 g |
Nyelv: | angol |
Illusztrációk: | 1 Illustrations, black & white; 70 Illustrations, color |
267 |
Témakör:
Hosszú leírás:
This textbook aims to describe the fascinating area of eukaryotic gene regulation for graduate students in all areas of the biomedical sciences. Gene expression is essential in shaping the various phenotypes of cells and tissues and as such, regulation of gene expression is a fundamental aspect of nearly all processes in physiology, both in healthy and in diseased states. Th is pivotal role for the regulation of gene expression makes this textbook essential reading for students of all the biomedical sciences, in order to be better prepared for their specialized disciplines. A complete understanding of transcription factors and the processes that alter their activity is a major goal of modern life science research. The availability of the whole human genome sequence (and that of other eukaryotic genomes) and the consequent development of next-generation sequencing technologies have significantly changed nearly all areas of the biological sciences. For example, the genome-wide location of histone modifications and transcription factor binding sites, such as provided by the ENCODE consortium, has greatly improved our understanding of gene regulation. Therefore, the focus of this book is the description of the post-genome understanding of gene regulation.
Tartalomjegyzék:
1 Genes and chromatin
1.1Central dogma of molecular biology
1.2Impact of chromatin structure
1.3Epigenetics enables gene expression
1.4Gene regulation in the context of nuclear architecture
2 Basal transcriptional machinery
2.1Core promoter
2.2TATA box and other core promoter elements
2.3Genome-wide core promoter identification
2.4TFIID and Mediator as paradigms of multi-protein complexes
3 Transcription factors and signal transduction
3.1Site-specific transcription factors and their domains3.2Classification of transcription factors
3.3.Activation of transcription factors
3.4Programing cellular differentiation by transcription factors
3.5Inflammatory signaling via NF-?B
3.6Sensing cellular stress via p534 A key transcription factor family: Nuclear receptors
4.1The nuclear receptor superfamily
4.2Molecular interactions of nuclear receptors
4.3Physiological role of nuclear receptors
5 Genome-wide principles of gene regulation
5.1Next-generation sequencing
5.2Gene regulation in the context of Big Biology
5.3Exploring genome-wide transcription factor binding
5.4Integrating epigenome-wide datasets
6 Chromatin modifiers
6.1Cytosines and their methylation
6.2Histone modifications
6.3Gene regulation via chromatin modifiers
6.4Sensing energy metabolism via chromatin modifiers
7 Epigenetics
7.1Epigenetics and chromatin
7.2Genome-wide understanding of epigenetics7.3CTCF and genetic imprinting
7.4Epigenetics in health and disease
8 Chromatin remodeling and organization
8.1Nucleosome positioning at promoters
8.2Chromatin remodeling
8.3Transcriptional dynamics in the presence of chromatin
8.4Organization of the nucleus
9 Regulatory impact of non-coding RNA
9.1Non-coding RNAs
9.2miRNAs and their regulatory potential
9.3Long ncRNAs
9.4Enhancer RNAs