LC-MS in Drug Analysis: Methods and Protocols

LC-MS in Drug Analysis

Methods and Protocols
 
Edition number: Softcover reprint of the original 2nd ed. 2019
Publisher: Humana
Date of Publication:
Number of Volumes: 1 pieces, Previously published in hardcover
 
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Product details:

ISBN13:9781493993970
ISBN10:1493993976
Binding:Paperback
No. of pages:274 pages
Size:254x178 mm
Weight:740 g
Language:English
Illustrations: 12 Illustrations, black & white; 24 Illustrations, color
169
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Short description:

This second edition provides detailed LC-MS(/MS) procedures for the analysis of compounds of clinical and toxicological significance. Chapters detail new and updated methods for analyzing drugs focusing on advances in technology, alternate matrices, and rapidly-changing classes of drugs of abuse, compounds pertinent to toxicology, and therapeutic agents. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.



Authoritative and cutting-edge, LC-MS in Drug Analysis: Methods and Protocols, Second Edition aims to ensure successful results in the further study of this vital field.

Long description:

This second edition provides detailed LC-MS(/MS) procedures for the analysis of compounds of clinical and toxicological significance. Chapters detail new and updated methods for analyzing drugs focusing on advances in technology, alternate matrices, and rapidly-changing classes of drugs of abuse, compounds pertinent to toxicology, and therapeutic agents. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.



 Authoritative and cutting-edge, LC-MS in Drug Analysis: Methods and Protocols, Second Edition aims to ensure successful reults in the further study of this vital field.

Table of Contents:

1. An Introduction to Drug Testing ? The Expanding Role of Mass Spectrometry



Christine L.H. Snozek, Loralie J. Langman, and Steven W. Cotten



 



2. Quantification of Eight Cannabinoids Including Cannabidiol in Human Urine Via Liquid Chromatography Tandem Mass Spectrometry



Karl B. Scheidweiler and Allan J. Barnes



 



3. Analysis of Benzodiazepines for Drug Facilitated Assaults and Abuse Settings (Urine)



Olaf H. Drummer, Matthew Di Rago, and Dimitri Gerostamoulos



 



4. Targeted Opioid Screening Assay for Pain Management Using High Resolution Mass Spectrometry



Darlington Danso, Loralie J. Langman, and Paul J. Jannetto



 



5. Measurement of Buprenorphine and Norbuprenorphine in Urine



Andrea R. Terrell, Vipin Adhlakha, and Poluru Reddy



 



6. Quantitation of Tapentadol by Liquid Chromatography ? Tandem Mass Spectrometry



Graham R. Jones and Russell P. Handy



 



7. Therapeutic Drug Monitoring of Lacosamide by LC-MS/MS



He Sarina Yang and Leslie Edinboro



 



8. LC-MS/MS method for the quantification of the Leflunomide metabolite, Teriflunomide, in Human Serum/Plasma



Geoffrey S. Rule, Alan L. Rockwood, and Kamisha L. Johnson-Davis



 



9. Analysis of Tryptic Peptides from Therapeutic Monoclonal Antibodies using LC-MS/MS



Maria Alice Vieira Willrich



 



10. Quantification of Methotrexate in Human Serum and Plasma by Liquid Chromatography Tandem Mass Spectrometry



Gabrielle N. Winston-McPherson, Michael Schmeling, and Andrew N. Hoofnagle



 



11. Simultaneous Determination of Tacrolimus and Cyclosporine A in Whole Blood by Ultra-Fast LC-MS/MS



Matthew W Bjergum, Paul J Jannetto,  and Loralie J Langman,



 



12. Liquid Chromatography-tandem Mass Spectrometry (LC-MS/MS) Method to Quantify Gabapentin and Pregabalin in Urine



Stephen Merrigan and Kamisha L. Johnson-Davis1



 



13. The Evolving Landscape of Designer Drugs



Sherri L. Kacinko and Donna M. Papsun



 



14. Analysis of Synthetic Cannabinoid Metabolites by Liquid Chromatography-Tandem Mass Spectrometry



Gregory C. Janis



 



15. Quantification of Designer Opioids by Liquid Chromatography Tandem Mass Spectrometry



Sherri L. Kacinko and Joseph W. Homan



 



16. Screening Analysis for Designer Stimulants by LC-MS/MS



Piotr Adamowicz and Bogdan Tokarczyk



 



17. Drug Screening Using Liquid Chromatography Quadrupole Time of Flight (LC-QqTOF) Mass Spectrometry



Jennifer M. Colby and Kara L. Lynch



 



18. Alternate Matrices ? Meconium, Cord Tissue, Hair, and Oral Fluid



Kendra L. Palmer and Matthew D. Krasowski



 



19. Salt-assisted Liquid-Liquid Extraction of Meconium for Analysis of Cocaine and Amphetamines by Liquid Chromatography-tandem Mass Spectrometry



Melissa M. Goggin and Gregory C. Janis



 



20. Detection of In Utero Cannabis Exposure in Umbilical Cord Tissue by A Sensitive Liquid Chromatography?Tandem Mass Spectrometry Method



Fang Wu, Triniti L. Scroggin, and Gwendolyn A. McMillin



 



21. Quantitation of Ethyl ?-D-glucuronide in Human Umbilical Cord Tissue by Liquid Chromatography Tandem Mass Spectrometry (LC-MS/MS)



Simuli L. Wabuyele and Gwendolyn A. McMillin



 



22. Analysis of Drugs in Oral Fluid using LC-MS/MS



Cynthia Coulter and Christine Moore



 



23. Determination of Cocaine and Metabolites in Dried Blood Spots by LC-MS/MS



Lars Ambach and Christophe Stove