Current Advances in the Science of Osteosarcoma: Research Perspectives: Tumor Biology, Organ Microenvironment, Potential New Therapeutic Targets, and Canine Models

Current Advances in the Science of Osteosarcoma

Research Perspectives: Tumor Biology, Organ Microenvironment, Potential New Therapeutic Targets, and Canine Models
 
Edition number: 2nd ed. 2020
Publisher: Springer
Date of Publication:
Number of Volumes: 1 pieces, Book
 
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Product details:

ISBN13:9783030430849
ISBN10:3030430847
Binding:Hardback
No. of pages:233 pages
Size:254x178 mm
Weight:671 g
Language:English
Illustrations: 11 Illustrations, black & white; 23 Illustrations, color; 50 Tables, color
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Short description:

This thoroughly revised second edition is an up-to-date overview of the new advances in the knowledge of the basic science in sarcoma and osteosarcoma. It features detailed, in-depth discussions of microRNAs in osteosarcoma, historical perspectives of chemotherapy in the treatment of the disease, tumor targeted IL12 therapy and HER2 targeted therapy, the role of enhancer elements in regulating the prometastatic transcriptional program and more. Further, this essential volume also includes new insights on Wnt signaling in osteosarcoma, the role of genomics, genetically modified T-cell therapy, liquid biopsy, oncolytic viruses, immunophenotyping, receptor tyrosine kinases and epigenetic-focused approaches for treatment of osteosarcoma metastases, as well as thoughts on the current standard of treatment for patients suffering from these cancers. In the years since the previous edition, there have been numerous new developments in this rapidly changing field; this new edition is both timely and urgently needed. When taken together these companion volumes, Current Clinical (Book 1) and Scientific (Book 2) Advances in Osteosarcoma, are a timely and urgently needed guide for laboratory investigators and clinical oncologists.

Long description:

This thoroughly revised second edition is an up-to-date overview of the new advances in the knowledge of the basic science in sarcoma and osteosarcoma. It features detailed, in-depth discussions of microRNAs in osteosarcoma, historical perspectives of chemotherapy in the treatment of the disease, tumor targeted IL12 therapy and HER2 targeted therapy, the role of enhancer elements in regulating the prometastatic transcriptional program and more. Further, this essential volume also includes new insights on Wnt signaling in osteosarcoma, the role of genomics, genetically modified T-cell therapy, liquid biopsy, oncolytic viruses, immunophenotyping, receptor tyrosine kinases and epigenetic-focused approaches for treatment of osteosarcoma metastases, as well as thoughts on the current standard of treatment for patients suffering from these cancers. In the years since the previous edition, there have been numerous new developments in this rapidly changing field; this new edition is both timely and urgently needed. When taken together these companion volumes, Current Clinical (Book 1) and Scientific (Book 2) Advances in Osteosarcoma, are a timely and urgently needed guide for laboratory investigators and clinical oncologists.

Table of Contents:

1The genomic complexity of osteosarcoma and its implication for preclinical and clinical targeted therapies

2Genomics and the Immune Landscape of Osteosarcoma

3RECQ DNA Helicases and Osteosarcoma

4Targeting the Cancer Epigenome with Histone Deacetylase Inhibitors in Osteosarcoma

5Oncolytic viruses and their potential as a therapeutic opportunity in Osteosarcoma

6Applying Osteosarcoma Immunology to Understand Disease Progression and Assess immunotherapeutic Response

7Targetable intercellular signaling pathways facilitate lung colonization in osteosarcoma

8Wnt Signaling in Osteosarcoma

9Receptor Tyrosine Kinases in Osteosarcoma: 2019 update

10The Role of ALDH in the Metastatic Potential of Osteosarcoma Cells and Potential ALDH Targets 

11Autophagy in OS

12Fas signaling as a potential target for the treatment of osteosarcoma metastasis in the lungs

13Exosomes: Dynamic Mediators of Extracellular Communication in the Tumor Microenvironment   

14Comparative Immunology and Immunotherapy of Canine Osteosarcoma

Index