Coenzyme Q in Aging
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| ISBN13: | 9783030456412 |
| ISBN10: | 3030456412 |
| Binding: | Hardback |
| No. of pages: | 369 pages |
| Size: | 235x155 mm |
| Weight: | 810 g |
| Language: | English |
| Illustrations: | 33 Illustrations, black & white; 17 Illustrations, color; 25 Tables, color |
| 235 |
This book offers a comprehensive exploration of research on the essential relationship of the coenzyme Q10 and the process of aging in living organisms. CoQ10 is an important factor in two main aspects of cell physiology: bioenergetics and antioxidant protection. While primary deficiency of CoQ10 is associated with severe and lethal disease, secondary deficiency can be associated with the progression of mitochondrial dysfunction linked to the lessening of biological activities during aging.
The book is organized in four sections. The first offers an overview of the function of CoQ10, highlighting the two main functions of CoQ10 in cells: its essential role as electron transport chain member in mitochondria, and the protection of cell membranes against oxidation as one of the main endogenous-synthesized antioxidants.
The second section covers research on Coenzyme 10. Topics include studies involving invertebrate models, mammal studies and the influence of CoQ on longevity. Also covered is research involving the role of CoQ in senescence-accelerated mice.
Section three examines the effects of reduced CoQ in human aging, as evident in mitochondrial dysfunction, metabolic syndrome, neurodegenerative disorders, immunosenescence and fertility and reproduction.
The final section, Prolongevity effectors and Coenzyme Q, explores research into slowing or stopping the aging process. Coverage includes strategies including calorie restriction, and modulation of CoQ10 levels by induction of synthesis or by supplementation.
Coenzyme Q in Aging benefits a broad readership of researchers, clinicians, educators and students interested in the biochemical and physiological effects of coenzyme Q and the importance of this molecule in aging process.
This book offers a comprehensive exploration of research on the essential relationship of the coenzyme Q10 and the process of aging in living organisms. CoQ10 is an important factor in two main aspects of cell physiology: bioenergetics and antioxidant protection. While primary deficiency of CoQ10 is associated with severe and lethal disease, secondary deficiency can be associated with the progression of mitochondrial dysfunction linked to the lessening of biological activities during aging.
The book is organized in four sections. The first offers an overview of the function of CoQ10, highlighting the two main functions of CoQ10 in cells: its essential role as electron transport chain member in mitochondria, and the protection of cell membranes against oxidation as one of the main endogenous-synthesized antioxidants.
The second section covers research on Coenzyme 10. Topics include studies involving invertebrate models, mammal studies and the influence of CoQ on longevity. Also covered is research involving the role of CoQ in senescence-accelerated mice.
Section three examines the effects of reduced CoQ in human aging, as evident in mitochondrial dysfunction, metabolic syndrome, neurodegenerative disorders, immunosenescence and fertility and reproduction.
The final section, Prolongevity effectors and Coenzyme Q, explores research into slowing or stopping the aging process. Coverage includes strategies including calorie restriction, and modulation of CoQ10 levels by induction of synthesis or by supplementation.
Coenzyme Q in Aging benefits a broad readership of researchers, clinicians, educators and students interested in the biochemical and physiological effects of coenzyme Q and the importance of this molecule in aging process.
Part 1. Basics on coenzyme Q
1. Introduction. The current coenzyme Q science and knowledge
Plácido Navas
2. Molecular structure, biosynthesis, and distribution of coenzyme Q
Luis Vázquez-Fonseca, Isabel González-Mariscal and Carlos Santos Oca?a
3. Coenzyme Q function in mitochondria
María Luisa Genova and Giorgio Lenaz
4. Extramitochondrial coenzyme Q10 in aging
Guillermo López Lluch
5. Regulation of the synthesis of Coenzyme Q10
María Victoria Cascajo Almenara and Guillermo López Lluch
Part 2. Coenzyme Q in aging studies.
6. Coenzyme Q and aging in C. elegans
Claudio Asencio Salcedo
7. Coenzyme Q and aging in the fruit fly Drosophila melanogaster
Daniel José Moreno Fernández-Ayala and Alberto Sanz
8. The aging process and coenzyme Q: clk-1 mouse models
Mayumi Takahashi, Kazuhide Takahashi and Takuji Shirasawa
9. Reduced coenzyme Q10 decelerates senescence and age-related hearing loss in senescence-accelerated mice by activating mitochondrial functions
Jinko Sawashita, Xu Zhe and Keiichi Higuchi
Part 3. Age-related diseases and coenzyme Q.
10. Coenzyme Q, mtDNA and mitochondrial dysfunction during aging
José Luis Quiles, Alfonso Varela-López, María Dolores Navarro-Hortal and Maurizio Battino
11. Coenzyme Q10 and metabolic syndrome
Juan Diego Hernández-Camacho
12. Coenzyme Q and age-related neurodegenerative disorders: Parkinson and Alzheimer diseases
Francisco J. Alcaín, Javier Domínguez, Mario Durán-Prado and Julia Vaamonde
13. Immunosenescence and CoQ10
Juan Diego Hernández-Camacho, Catherine Meza-Torres and Guillermo López-Lluch
14. Coenzyme Q10 in fertility and reproduction
Diana Vaamonde, Antony C. Hackney, Carolina Algar-Santacruz, María José García-Moreno and Juan Manuel García-Manso
Part 4. Prolongevity effectors and Coenzyme Q.
15. Calorie restriction, longevity and coenzyme Q
María Isabel Burón, Cristina Parrado, José Antonio González-Reyes, Lucía Fernández del Río, Elena Gutiérrez-Casado, Miguel Calvo-Rubio, Sandra Rodríguez-López and José Manuel Villalba.
16. Age dependent changes of coenzyme Q levels and its induction in experimental systems
Magnus Bentinger, Gustav Dallner, Kerstin Brismar, Ewa Swiezewska and Michael Tekle
17. Effects of coenzyme Q10 supplementation on elderly people
Elena M. Yubero-Serrano, Francisco M. Gutierrez-Mariscal, José López-Miranda,
